中山醫學大學機構典藏 CSMUIR:Item 310902500/23851
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    题名: The Development of Light-Curable Calcium-Silicate-Containing Composites Used in Odontogenic Regeneration
    作者: Lin, YT;Shie, MY;Lin, YH;Ho, CC;Kao, CZ;Huang, SH
    关键词: calcium silicate;polyethylene glycol diacrylate;light curing;dental pulp stem cells;odontogenesis
    日期: 2021
    上传时间: 2022-08-05T09:43:55Z (UTC)
    出版者: MDPI
    摘要: Pulp regeneration is one of the most successful areas in the field of tissue regeneration, despite its current limitations. The biocompatibility of endodontic biomaterials is essential in securing the oral microenvironment and supporting pulp tissue regeneration. Therefore, the objective of this study was to investigate the new light-curable calcium silicate (CS)-containing polyethylene glycol diacrylate (PEGDA) biocomposites' regulation of human dental pulp stem cells (hDPSCs) in odontogenic-related regeneration. The CS-containing PEGDA (0 to 30 wt%) biocomposites are applied to endodontics materials to promote their mechanical, bioactive, and biological properties. Firstly, X-ray diffraction and Fourier-transform infrared spectroscopy showed that the incorporation of CS increased the number of covalent bonds in the PEGDA. The diameter tension strength of the CS-containing PEGDA composite was significantly higher than that of normal PEGDA, and a different microstructure was detected on the surface. Samples were analyzed for their surface characteristics and Ca/Si ion-release profiles after soaking in simulated body fluid for different periods of time. The CS30 group presented better hDPSC adhesion and proliferation in comparison with CS0. Higher values of odontogenic-related biomarkers were found in hDPSCs on CS30. Altogether, these results prove the potential of light-curable CS-containing PEGDA composites as part of a 'point-of-care' strategy for application in odontogenesis-related regeneration.
    URI: http://dx.doi.org/10.3390/polym13183107
    https://www.webofscience.com/wos/woscc/full-record/WOS:000701125200001
    https://ir.csmu.edu.tw:8080/handle/310902500/23851
    關聯: POLYMERS ,2021,v13,issue 18
    显示于类别:[中山醫學大學研究成果] 期刊論文

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