Gender Difference in the Relationships between Inflammatory Markers, Serum Uric Acid and Framingham Risk Score

doi:10.3390/ijerph18137103

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23809

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23809

Title:	Gender Difference in the Relationships between Inflammatory Markers, Serum Uric Acid and Framingham Risk Score
Authors:	Huang, JH;Li, RH;Huang, SL;Sia, HK;Yu, CH;Tang, FC
Keywords:	Framingham Risk Score;high-sensitivity C-reactive protein;white blood cell;serum uric acid;cardiovascular disease;gender
Date:	2021
Issue Date:	2022-08-05T09:43:13Z (UTC)
Publisher:	MDPI
Abstract:	The purpose of the present study was to explore the role of gender in the relation of high-sensitivity C-reactive protein (hsCRP), white blood cell (WBC) count, and serum uric acid (UA) to the risk of future cardiovascular disease (CVD) events. In total, 404 workers were recruited to obtain the measurements of serum markers for CVD risk. Demographic data, nutrition, exercise, smoking, and alcohol consumption were assessed through a questionnaire. The Framingham Risk Score (FRS) was adopted to estimate the risk of future CVD events. Multiple linear regression models were used to determine CVD risk markers in relation to the FRS by gender. The hsCRP was not significantly correlated with the FRS for all workers after adjusting for covariates, including demographic data and health-related lifestyle. WBC count was positively correlated with FRS for all workers, but WBC count did not show an interaction with gender with respect to the FRS. Serum UA showed an interaction with gender on the FRS, and UA positively correlated with the FRS in males though not in females. With respect to CVD prevention, the WBC count can be used to monitor the risk for all workers. Due to a gender difference shown in the relationship between serum UA and the FRS, serum UA can be a monitor of the risk of future CVD events in male workers only.
URI:	http://dx.doi.org/10.3390/ijerph18137103 https://www.webofscience.com/wos/woscc/full-record/WOS:000671609600001 https://ir.csmu.edu.tw:8080/handle/310902500/23809
Relation:	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH ,2021,v18,issue 13
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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