A Taiwanese study on real-world evidence with vortioxetine in patients with major depression in Asia (TREVIDA)

doi:10.1080/03007995.2021.1980869

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23797

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23797

Title:	A Taiwanese study on real-world evidence with vortioxetine in patients with major depression in Asia (TREVIDA)
Authors:	Yang, YK;Chen, CS;Tsai, CF;Chang, CM;Lai, TJ;Lee, CT;Lin, CC;Lan, TH;Herr, KJ
Keywords:	Cognition;major depressive disorder;Taiwan;vortioxetine;work performance
Date:	2021
Issue Date:	2022-08-05T09:43:02Z (UTC)
Publisher:	TAYLOR & FRANCIS LTD
ISSN:	0300-7995
Abstract:	Objective The TREVIDA study aimed to evaluate vortioxetine for the treatment of major depressive disorder (MDD) in Taiwanese adults. Methods Patients with active depressive episode were recruited in this non-interventional, prospective, multi-site study conducted between June 2019 and August 2020 in Taiwan. Patient eligibility was independent of the physician's decision to prescribe vortioxetine for an MDD episode. Vortioxetine was initiated on the first visit. Depression severity, cognitive function, work productivity, functioning and safety were evaluated over 3 months. Results Overall, 242 patients were analyzed. At baseline, 70.7% and 90.4% of patients had moderately severe-to-severe depression based on PHQ-9 (Patient Health Questionnaire-9) and TDQ (Taiwanese Depression Questionnaire), respectively. By Month 3, significant improvements from baseline in depression severity (mean [SD] changes in PHQ-9, TDQ and CGI-S [Clinical Global Impression-Severity]: -6.3 [7.3]; -13.2 [14.0]; -1.5 [1.3], respectively), cognitive function (mean [SD] change in PDQ-D: -8.0 [17.5]), functioning (mean [SD] change in SDS: -5.4 [7.6]), and presenteeism (38.9% from 56.3%), work productivity loss (40.9% from 58.7%) and activity impairment (43.2% from 61.0%) were observed (p < .001 for all). By month 3, patient-reported (PHQ-9) response and remission rates were 43.4% and 52.9%, respectively; physician-reported (CGI-S) response and remission rates were 29.0% and 31.6%, respectively. Vortioxetine was well-tolerated and no unexpected side effects were reported. Conclusions Vortioxetine reduced depression severity and improved cognitive function, work productivity, and functioning in Taiwanese patients with MDD in the real-world setting. Vortioxetine was well-tolerated in this Taiwanese population.
URI:	http://dx.doi.org/10.1080/03007995.2021.1980869 https://www.webofscience.com/wos/woscc/full-record/WOS:000702702500001 https://ir.csmu.edu.tw:8080/handle/310902500/23797
Relation:	CURRENT MEDICAL RESEARCH AND OPINION ,2021,v37,issue 12, P2163-2173
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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