中山醫學大學機構典藏 CSMUIR:Item 310902500/23753
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17901/22917 (78%)
造访人次 : 7553820      在线人数 : 218
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23753


    题名: Downregulation of Notch3 links TIMP3 inhibition to suppress aggressive phenotypes of pancreatic ductal adenocarcinoma
    作者: Chiu, TJ;Chen, YJ;Lan, J;Chen, YY;Chen, YC;Lin, HW;Tsai, HT;Lin, YS;Hsiao, CC;Chen, CH
    关键词: Pancreatic ductal adenocarcinoma;Notch3;TIMP3;gemcitabine;motility
    日期: 2021
    上传时间: 2022-08-05T09:42:19Z (UTC)
    出版者: E-CENTURY PUBLISHING CORP
    ISSN: 2156-6976
    摘要: Pancreatic ductal adenocarcinoma (PDAC), one of the most deadly digestive cancers, has a poor 5-year survival rate and is resistant to chemotherapeutic agents, such as gemcitabine. Notch3 plays an important role in cancer progression, and its expression facilitates chemoresistance in cancers. This study examined the clinical significance of Notch3 and explored the mechanisms through which it may affect disease progression in PDAC. We found Notch3 to be upregulated in PDAC patients in whom it correlated with lymph node stage and poor survival. In vitro and in vivo, functional assays indicated that silencing Notch3 could suppress the growth, migration, invasion of PDAC cells and sensitize PDAC cells to gemcitabine. QPCR array, which was performed to elucidate the Notch3-regulated pathway, revealed that inhibition of Notch3 decreased the transcription and secretion of TIMP3 in PDAC cells. Overexpression of TIMP3 reversed the impaired growth, migration, invasion, and chemosensitivity induced by Notch3 silencing. We also found a positive correlation between Notch3 mRNA expression and TIMP3 expression in patients with PDAC. We concluded that blocking Notch3/TIMP3 pathway could considered a potentially new therapeutic strategy for treating PDAC.
    URI: https://www.webofscience.com/wos/woscc/full-record/WOS:000727777200028
    https://ir.csmu.edu.tw:8080/handle/310902500/23753
    關聯: AMERICAN JOURNAL OF CANCER RESEARCH ,2021,v11,issue 11, P5609-+
    显示于类别:[中山醫學大學研究成果] 期刊論文

    文件中的档案:

    没有与此文件相关的档案.



    SFX Query

    在CSMUIR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈