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https://ir.csmu.edu.tw:8080/ir/handle/310902500/23741
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| 题名: | Original Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells |
| 作者: | Wei, KC;Lin, YC;Chen, CH;Chu, YH;Huang, CY;Liao, WC;Liu, CH |
| 关键词: | Fucosyltransferase 8;glioma;HGF;MET;EGFR |
| 日期: | 2021 |
| 上传时间: | 2022-08-05T09:42:07Z (UTC)
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| 出版者: | E-CENTURY PUBLISHING CORP |
| ISSN: | 2156-6976 |
| 摘要: | Alteration of extracellular glycosylation is a hallmark of malignant characteristics. In this study, we re-vealed that fucosyltransferase 8 (FUT8), an enzyme that mediates the core fucosylation of N-linked glycosylation, is an important regulator of malignant characteristics in human glioma that acts by modifying the activities of both the HGF receptor (MET) and epidermal growth factor receptor (EGFR). mRNA and protein expression levels of FUT8 were frequently upregulated in gliomas, and these events were showed positive correlations with advanced tumor grade, recurrence, and decreased overall survival. Silencing FUT8 expression in glioma cells suppressed cell growth, migration, and invasion, whereas overexpression of FUT8 was sufficient to enhance these phenotypes. Mechanistic investigations revealed that FUT8 was involved in the alteration of fucosylation status that was attached to MET and EGFR, changing MET responses after HGF stimulation, as well as in the transactivation of EGFR. Importantly, altering FUT8 expression or using the fucosylation inhibitor 2F-peracetyl-fucose sensitized the efficacy of of temo-zolomide (TMZ) therapy. Collectively, these results suggested that FUT8 dysregulation contributed to the malignant behaviors of glioma cells and provide novel insights into the significance of fucosylation in receptor tyrosine kinase activity and TMZ resistance. |
| URI: | https://www.webofscience.com/wos/woscc/full-record/WOS:000727777200018
https://ir.csmu.edu.tw:8080/handle/310902500/23741 |
| 關聯: | AMERICAN JOURNAL OF CANCER RESEARCH ,2021,v11,issue 11, P5472-+ |
| 显示于类别: | [中山醫學大學研究成果] 期刊論文
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