Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds

doi:10.3390/cells10113264

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Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23738

Title:	Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds
Authors:	Tsai, WH;Chou, CH;Huang, TY;Wang, HL;Chien, PJ;Chang, WW;Lee, HT
Keywords:	heat-killed probiotics;Lactobacillus;L;plantarum;L;paracasei;skin wound healing;lipoteichoic acid
Date:	2021
Issue Date:	2022-08-05T09:42:05Z (UTC)
Publisher:	MDPI
Abstract:	Probiotics are defined as microorganisms with beneficial health effects when consumed by humans, being applied mainly to improve allergic or intestinal diseases. Due to the increasing resistance of pathogens to antibiotics, the abuse of antibiotics becomes inefficient in the skin and in systemic infections, and probiotics may also provide the protective effect for repairing the healing of infected cutaneous wounds. Here we selected two Lactobacillus strains, L. plantarum GMNL-6 and L. paracasei GMNL-653, in heat-killed format to examine the beneficial effect in skin wound repair through the selection by promoting collagen synthesis in Hs68 fibroblast cells. The coverage of gels containing heat-killed GMNL-6 or GMNL-653 on the mouse tail with experimental wounds displayed healing promoting effects with promoting of metalloproteinase-1 expression at the early phase and reduced excessive fibrosis accumulation and deposition in the later tail-skin recovery stage. More importantly, lipoteichoic acid, the major component of Lactobacillus cell wall, from GMNL-6/GMNL-653 could achieve the anti-fibrogenic benefit similar to the heat-killed bacteria cells in the TGF-beta stimulated Hs68 fibroblast cell model. Our study offers a new therapeutic potential of the heat-killed format of Lactobacillus as an alternative approach to treating skin healing disorders.
URI:	http://dx.doi.org/10.3390/cells10113264 https://www.webofscience.com/wos/woscc/full-record/WOS:000807195900001 https://ir.csmu.edu.tw:8080/handle/310902500/23738
Relation:	CELLS ,2021,v10,issue 11
Appears in Collections:	[researcher portal] Artical

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