Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic-Ischemic Encephalopathy

doi:10.3390/diagnostics11112056

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23723

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23723

Title:	Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic-Ischemic Encephalopathy
Authors:	Chen, DY;Lee, IC;Wang, XA;Wong, SH
Keywords:	newborn;HIE;biomarker;hearing impairment;neurodevelopment
Date:	2021
Issue Date:	2022-08-05T09:41:50Z (UTC)
Publisher:	MDPI
Abstract:	Identifying biomarkers for hearing impairments (HIs) in patients with neonatal hypoxic-ischemic encephalopathy (HIE), to initialize early hearing habilitation, is crucial. Seventy-eight neonates with HIE were divided into the following two groups: those with HIs and those without HIs. We compared those patients with 11,837 newborns without HIE, and analyzed the risk factors of HIs among neonatal HIE. Of the 78 patients, 11 were confirmed to have an HI, which is a substantially higher percentage than in the 11,837 newborns without HIE (14.1% vs. 0.87%; p < 0.001). More patients with moderate-to-severe HIE had confirmed HIs (p = 0.020; odds ratio, 8.61) than those with mild HIE. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE. The patients who exhibited HIs had significantly higher lactate (104.8 & PLUSMN; 51.0 vs. 71.4 & PLUSMN; 48.4; U = 181, p = 0.032) and serum glucose (159.5 & PLUSMN; 86.1 vs. 112.1 & PLUSMN; 62.3; U = 166, p = 0.036) levels than those without HIs. A higher prevalence of HIs was noted in the patients with stage III HIE than those with stage II HIE (43.8% vs. 10%; p = 0.008). The degree of HI correlated with brain anomalies and neurodevelopmental outcomes at 1 year of age. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE.
URI:	http://dx.doi.org/10.3390/diagnostics11112056 https://www.webofscience.com/wos/woscc/full-record/WOS:000725775300001 https://ir.csmu.edu.tw:8080/handle/310902500/23723
Relation:	DIAGNOSTICS ,2021,v11,issue 11
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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