Association of Prenatal Maternal Anemia with Tics and Tourette's Syndrome in Offspring

doi:10.3390/jpm11101038

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23710

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23710

Title:	Association of Prenatal Maternal Anemia with Tics and Tourette's Syndrome in Offspring
Authors:	Liu, YC;Chen, VCH;Liao, YT;Chen, YL
Keywords:	tics;Tourette's syndrome;prenatal anemia;maternal anemia;iron deficiency anemia
Date:	2021
Issue Date:	2022-08-05T09:41:39Z (UTC)
Publisher:	MDPI
Abstract:	Iron deficiency anemia (IDA) accounts for most of the anemia in pregnancy, and iron is essential for neurodevelopment. Tics and Tourette's syndrome (TS) are neurodevelopmental disorders that manifest in childhood. A few studies reported an inconclusive association between iron deficiency and tics in children. No study has investigated the relationship between prenatal maternal anemia and tics in children. We aimed to assess the relationship between prenatal anemia exposure and the incidence of tics or TS in offspring. We linked the Taiwan National Health Insurance Research Database to the Maternal and Child Health Database for the analysis and identified 153,854 children with prenatal anemia exposure and 2,014,619 children without prenatal anemia exposure from 2004 to 2016 and followed them through 2017. Cox regression models were applied to compare the risk of tics or TS between the exposed and nonexposed groups. Among the exposed group, 37,832 were exposed at <= 12 weeks of gestational age (GA) and 116,022 at > 12 weeks of GA. We observed an increased risk of tics and TS in those exposed at <= 12 weeks compared with the nonexposed group (adjusted hazard ratio (aHR) = 1.23, 95% confidence interval (CI): 1.12-1.34). The result remained consistent after adjusting for birth year, sex, birth order, maternal age, low-income levels, gestational age, birth weight, and alcohol use and smoking during pregnancy (aHR = 1.16, CI: 1.04-1.28). Fetuses exposed to maternal anemia at <= 12 weeks of GA are at high risk of tics or TS. However, this effect was attenuated to insignificance in the sibling comparison. Our study highlights the importance of detection of anemia during pregnancy and proper timing of iron supplementation.
URI:	http://dx.doi.org/10.3390/jpm11101038 https://www.webofscience.com/wos/woscc/full-record/WOS:000715318200001 https://ir.csmu.edu.tw:8080/handle/310902500/23710
Relation:	JOURNAL OF PERSONALIZED MEDICINE ,2021,v11,issue 10
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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