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    Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23697


    Title: Kaempferol inhibits the cell migration of human hepatocellular carcinoma cells by suppressing MMP-9 and Akt signaling
    Authors: Ju, PC;Ho, YC;Chen, PN;Lee, HL;Lai, SY;Yang, SF;Yeh, CB
    Keywords: HCC;kaempferol;migration;MMP-9
    Date: 2021
    Issue Date: 2022-08-05T09:41:26Z (UTC)
    Publisher: WILEY
    ISSN: 1520-4081
    Abstract: Metastasis is the most prevalent cause of cancer-related deaths and treatment failure in patients with hepatocellular carcinoma (HCC). Kaempferol is a natural flavonol belonging to the subgroup of flavonoids and exhibits potent anticancer activities. This study provides molecular evidence on the anti-invasive and anti-migratory effects of kaempferol on human HCC cells. The anti-invasive effect was investigated by applying kaempferol on two human HCC cell lines (Huh-7 and SK-Hep-1). Kaempferol reduced the invasion and migration of Huh-7 and SK-Hep-1 cells by Boyden chamber invasion assay and wound healing assay, respectively. A protease array analysis showed that Matrix Metalloproteinase-9 (MMP-9) was dramatically downregulated in HCC cells after kaempferol treatment. Gelatin zymography and Western blot assay showed that kaempferol reduced the activities and protein expression of MMP-9, respectively. Kaempferol also sufficiently suppressed the phosphorylation of the Akt expression. Overall, kaempferol inhibited the invasive properties of human HCC cells by targeting MMP-9 and Akt pathways. Hence, kaempferol could be used as an adjuvant therapeutic agent for the treatment of human HCC cells.
    URI: http://dx.doi.org/10.1002/tox.23316
    https://www.webofscience.com/wos/woscc/full-record/WOS:000664750000001
    https://ir.csmu.edu.tw:8080/handle/310902500/23697
    Relation: ENVIRONMENTAL TOXICOLOGY ,2021,v36,issue 10, P1981-1989
    Appears in Collections:[中山醫學大學研究成果] 期刊論文

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