Ailanthoidol, a Neolignan, Suppresses TGF-beta 1-Induced HepG2 Hepatoblastoma Cell Progression

doi:10.3390/biomedicines9091110

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23682

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23682

Title:	Ailanthoidol, a Neolignan, Suppresses TGF-beta 1-Induced HepG2 Hepatoblastoma Cell Progression
Authors:	Tseng, TH;Lee, HJ;Lee, YJ;Lee, KC;Shen, CH;Kuo, HC
Keywords:	Ailanthoidol;TGF-beta 1;p-38MAPK;anti-hepatic cancer progression
Date:	2021
Issue Date:	2022-08-05T09:41:12Z (UTC)
Publisher:	MDPI
Abstract:	Ailanthoidol (ATD), a neolignan, possessed an antitumor promotion effect in the mouse skin model in our previous investigation. However, other antitumor properties remain to be elucidated. Liver cancer is a major cause of death in the world, and its prognosis and survival rate are poor. Therefore, the prevention and therapy of liver cancer have received much attention. TGF (transforming growth factor)-beta 1, a cytokine, plays a critical role in the progression of liver cancer. This study determined the inhibitory effects of ATD on the migration and invasion induced by TGF-beta 1 in HepG2 hepatoblastoma cells. Furthermore, ATD reduced the TGF-beta 1-promoted colony number of HepG2 hepatoblastoma cells. In addition to reversing TGF-beta 1-induced cell scattering, ATD suppressed TGF-beta 1-induced expression of integrin alpha 3, vimentin, N-cadherin, and matrix metalloproteinase 2 (MMP2). Finally, this study found that ATD significantly inhibited TGF-beta 1-promoted phosphorylation of p-38 mitogen-activated protein kinase (MAPK) and Smad 2. Furthermore, the administration of SB203580 (p38MAPK inhibitor) suppressed TGF-beta 1-induced expression of integrin alpha 3, N-cadherin, and MMP2. These results demonstrate a novel mechanism of ATD against progression of liver cancer.
URI:	http://dx.doi.org/10.3390/biomedicines9091110 https://www.webofscience.com/wos/woscc/full-record/WOS:000699141800001 https://ir.csmu.edu.tw:8080/handle/310902500/23682
Relation:	BIOMEDICINES ,2021,v9,issue 9
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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