中山醫學大學機構典藏 CSMUIR:Item 310902500/23621
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    题名: TGR5 Expression Is Associated with Changes in the Heart and Urinary Bladder of Rats with Metabolic Syndrome
    作者: Hsu, CC;Cheng, KC;Li, YX;Hsu, PH;Cheng, JT;Niu, HS
    关键词: metabolic syndrome;TGR5;etanercept;heart;urinary bladder;rats
    日期: 2021
    上传时间: 2022-08-05T09:40:14Z (UTC)
    出版者: MDPI
    摘要: Adipose-derived cytokines may contribute to the inflammation that occurs in metabolic syndrome (MetS). The Takeda G protein-coupled receptor (TGR5) regulates energy expenditure and affects the production of pro-inflammatory biomarkers in metabolic diseases. Etanercept, which acts as a tumor necrosis factor (TNF)-alpha antagonist, can also block the inflammatory response. Therefore, the interaction between TNF-alpha and TGR5 expression was investigated in rats with high-fat diet (HFD)-induced obesity. Heart tissues isolated from the HFD-induced MetS rats were analyzed. Changes in TGR5 expression were investigated with lithocholic acid (LCA) as the agonist. Betulinic acid (BA) was used to activate TGR5 in urinary bladders. LCA was more effective in the heart tissues of HFD-fed rats, although etanercept alleviated the function of LCA. STAT3 activation and higher TGR5 expression were observed in the heart tissues collected from HFD-fed rats. Thus, cardiac TGR5 expression is promoted by HFD through STAT3 activation in rats. Moreover, the urinary bladders of female rats fed a HFD showed a low response, which was reversed by etanercept. Relaxation by BA in the bladders was more marked in HFD-fed rats. The high TGR5 expression in HFD-fed rats was characterized using a mRNA assay, and the increased cAMP levels were found to be stimulated by BA in the isolated bladders. Therefore, TGR5 expression increases with a HFD in both the hearts and urinary bladders. Collectively, cytokine-medicated TGR5 activation was observed in the hearts and urinary bladders of rats.
    URI: http://dx.doi.org/10.3390/life11070695
    https://www.webofscience.com/wos/woscc/full-record/WOS:000676828200001
    https://ir.csmu.edu.tw:8080/handle/310902500/23621
    關聯: LIFE-BASEL ,2021,v11,issue 7
    显示于类别:[中山醫學大學研究成果] 期刊論文

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