Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo

doi:10.1042/BSR20211143

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23613

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23613

Title:	Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo
Authors:	Huang, NC;Huang, RL;Huang, XF;Chang, KF;Lee, CJ;Hsiao, CY;Lee, SC;Tsai, NM
Date:	2021
Issue Date:	2022-08-05T09:40:07Z (UTC)
Publisher:	PORTLAND PRESS LTD
ISSN:	0144-8463
Abstract:	Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and accounts for the fourth leading cause of all cancer deaths. Scientific evidence has found that plant extracts seem to be a reliable choice due to their multitarget effects against HCC. Juniperus communis has been used for centuries in traditional medicine and its anticancer properties have been reported. As a result, the purpose of the study was to investigate the anticancer effect and mechanism of J. communis extract (JCo extract) on HCC in vitro and in vivo. In the present study, we found that JCo extract inhibited the growth of human HCC cells by inducing cell cycle arrest at the G0/G1 phase, extensive apoptosis and suppressing metastatic protein expressions in HCC cells. Moreover, the combinational treatment of JCo and VP-16 was found to enhance the anticancer effect, revealing that JCo extract might have the potential to be utilized as an adjuvant to promote HCC treatment. Furthermore, in vivo study, JCo extract significantly suppressed HCC tumor growth and extended the lifespan with no or low systemic and pathological toxicity. JCo extract significantly up-regulated the expression of pro-apoptotic proteins and tumor suppressor p53, suppressed VEGF/VEGFR autocrine signaling, down-regulated cell cycle regulatory proteins and MMP2/MMP9 proteins. Overall, our results provide a basis for exploiting JCo extract as a potential anticancer agent against HCC.
URI:	http://dx.doi.org/10.1042/BSR20211143 https://www.webofscience.com/wos/woscc/full-record/WOS:000704005700020 https://ir.csmu.edu.tw:8080/handle/310902500/23613
Relation:	BIOSCIENCE REPORTS ,2021,v41,issue 7
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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