Fibromyalgia and periodontitis: Bidirectional associations in population-based 15-year retrospective cohorts

doi:10.1002/JPER.21-0256

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23595

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23595

Title:	Fibromyalgia and periodontitis: Bidirectional associations in population-based 15-year retrospective cohorts
Authors:	Ma, KSK;Lai, JN;Veeravalli, JJ;Chiu, LT;Van Dyke, TE;Wei, JCC
Keywords:	chronic pain;fatigue;infections;inflammation;musculoskeletal diseases;rheumatic diseases
Date:	2021
Issue Date:	2022-08-05T09:39:49Z (UTC)
Publisher:	WILEY
ISSN:	0022-3492
Abstract:	Background To determine the bidirectional link between periodontitis and fibromyalgia. Methods In this cohort study, 196,428 periodontitis patients and 196,428 propensity score-matched non-periodontitis controls were enrolled. A Cox proportional hazard model was utilized to estimate the risk of fibromyalgia and survival analysis was adopted to assess the time-dependent effect of periodontitis on fibromyalgia. Subgroup analyses stratified by age, sex, and tracking period were conducted to identify susceptible populations. A parallel and symmetrical cohort that recruited 141,439 fibromyalgia patients and 141,439 propensity score-matched non-fibromyalgia controls ascertained the inverse effect of fibromyalgia on incident periodontitis. Results Patients with periodontitis were more likely to develop fibromyalgia than non-periodontitis controls (HR = 1.42, 95% CI = 1.39-1.44, P < 0.001), which persisted in the survival analysis (log-rank test P < 0.0001). This effect was significant in both sexes and all age subgroups, and was particularly evident in males (HR = 1.52, 95% CI = 1.48-1.56, P < 0.001) and younger periodontitis patients (HR = 1.55, 95% CI = 1.50-1.60, P < 0.001). Fibromyalgia patients who never had periodontitis presented with greater risk for periodontitis over time (HR = 1.43, 95% CI = 1.40 - 1.45, P P < 0.0001). Conclusions Patients of both sexes and all age subgroups with periodontitis presented with a greater risk of fibromyalgia. Subgroups that were the most susceptible to periodontitis-associated fibromyalgia were periodontitis patients that were males and below 30 years old. Risks of periodontitis were also greater in fibromyalgia patients who never had periodontitis.
URI:	http://dx.doi.org/10.1002/JPER.21-0256 https://www.webofscience.com/wos/woscc/full-record/WOS:000727435000001 https://ir.csmu.edu.tw:8080/handle/310902500/23595
Relation:	JOURNAL OF PERIODONTOLOGY ,2022,v93,issue 6, P877-887
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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