数据加载中.....
|
jsp.display-item.identifier=請使用永久網址來引用或連結此文件:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/23588
|
| 题名: | Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model |
| 作者: | Liu, CH;Liao, WC;Li, HH;Tseng, LH;Wang, WH;Tung, H;Lin, PJ;Jao, HT;Liu, WY;Hung, CS;Lin, CL;Ho, YJ |
| 关键词: | clavulanic acid;cognitive function;epilepsy;glutamate;seizure;valproic acid |
| 日期: | 2021 |
| 上传时间: | 2022-08-05T09:39:42Z (UTC)
|
| 出版者: | WILEY |
| ISSN: | 0767-3981 |
| 摘要: | Epilepsy, which is caused by abnormal neuronal firing in the brain, is a common neurological disease and affects motor and cognitive functions. Excessive levels of glutamate and insufficient levels of inhibitory GABA are involved in its pathophysiology. Valproic acid (Val), a GABAergic agonist, is one of the first-line antiepileptic drugs, but it shows many adverse side effects at the clinical dose. Clavulanic acid (CA), a beta-lactamase inhibitor, has been demonstrated to increase glutamate transporter-1 expression. This study evaluated the effects of CA and Val in an epilepsy rat model. Male Wistar rats received intraperitoneal injections of pentylenetetrazol (PTZ, 35 mg/kg, every other day, IP, for 13 days) to induce kindling epilepsy. After four times of PTZ injection, rats received daily treatment with CA (1 or 10 mg/kg, IP), Val (50 or 100 mg/kg, IP), or the combination of CA (1 mg/kg) and Val (50 mg/kg) for 7 consecutive days. Motor, learning, and memory functions were measured. Rats with PTZ-induced kindling exhibited seizures, motor dysfunction, cognitive impairment, and cell loss and reduction of neurogenesis in the hippocampus. Neither 1 mg/kg CA nor 50 mg/kg Val treatment was effective in alleviating behavioral and neuronal deficits. However, treatment with 10 mg/kg CA, 100 mg/kg Val, and the combination of 1 mg/kg CA and 50 mg/kg Val improved these behavioral and neuronal deficits. Particularly, the combination of CA and Val showed synergistic effects on seizure suppression, suggesting the potential for treating epilepsy and related neuronal damage and motor and cognitive deficits. |
| URI: | http://dx.doi.org/10.1111/fcp.12729
https://www.webofscience.com/wos/woscc/full-record/WOS:000700804200001
https://ir.csmu.edu.tw:8080/handle/310902500/23588 |
| 關聯: | FUNDAMENTAL & CLINICAL PHARMACOLOGY ,2021,v35,issue 6, P1032-1044 |
| 显示于类别: | [中山醫學大學研究成果] 期刊論文
|
文件中的档案:
| 档案 |
描述 |
大小 | 格式 | 浏览次数 |
|---|
| index.html | | 0Kb | HTML | 196 | 检视/开启 |
|
在CSMUIR中所有的数据项都受到原著作权保护.
|
