Pogostemon cablin extract as an anticancer agent on human acute myeloid leukemia

doi:10.1002/fsn3.2282

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23586

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23586

Title:	Pogostemon cablin extract as an anticancer agent on human acute myeloid leukemia
Authors:	Chien, JH;Huang, XF;Lai, WL;Chang, KF;Li, CY;Chen, SY;Wu, CY;Li, KY;Tsai, NM
Keywords:	acute myeloid leukemia;anticancer;apoptosis;cell cycle;Pogostemon cablin
Date:	2021
Issue Date:	2022-08-05T09:39:40Z (UTC)
Publisher:	WILEY
ISSN:	2048-7177
Abstract:	Pogostemon cablin has been indicated to treat many kinds of diseases and the progression of cancers, such as colorectal cancer. However, the effects of P. cablin extract (PPa extract) against acute myeloid leukemia have not been investigated. Thus, this study explored the anticancer potential of PPa extract and its mechanism in HL-60 cells. The MTT assay results showed that PPa extract significantly inhibited the proliferation of HL-60 cells in a dose-dependent manner and affected cell morphology, causing cell shrinkage and the formation of debris. PPa extract blocked cell cycle progression at the G(0)/G(1) phase in a dose- and time-dependent manner and induced cell apoptosis, as shown by the observation of DNA fragments and apoptotic bodies. Furthermore, PPa extract caused the accumulation of a population of cells at G(0)/G(1) phase via a reduction in p-Rb, increasing p21 expression, and downregulating cell cycle regulator protein expression. Then, PPa extract was found to activate the extrinsic and intrinsic apoptosis pathways, leading to cell death. These data demonstrated that PPa extract exerted inhibitory activity and triggered cell apoptosis in HL-60 cells and that PPa extract might be a chemopreventive agent for cancer therapy.
URI:	http://dx.doi.org/10.1002/fsn3.2282 https://www.webofscience.com/wos/woscc/full-record/WOS:000645995900001 https://ir.csmu.edu.tw:8080/handle/310902500/23586
Relation:	FOOD SCIENCE & NUTRITION ,2021,v9,issue 6, P3209-3218
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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