Allergic rhinitis as a key factor for the development of gastroesophageal reflux disease in children

doi:10.1016/j.jmii.2020.08.008

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23581

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23581

Title:	Allergic rhinitis as a key factor for the development of gastroesophageal reflux disease in children
Authors:	Feng, MC;Tsai, YG;Chang, YH;Kuo, CH;Lin, YC;Hung, CH
Keywords:	ROC;Allergic rhinitis (AR);Asthma;Gastroesophageal reflux disease (GERD);Children
Date:	2021
Issue Date:	2022-08-05T09:39:36Z (UTC)
Publisher:	ELSEVIER TAIWAN
ISSN:	1684-1182
Abstract:	Background: Gastroesophageal reflux disease (GERD) may cause airway symptoms and some airway diseases exacerbate GERD symptoms. Asthma and allergic rhinitis (AR) have been identified as united airway disease because of their similar epidemiology and pathophysiology. Asthma has been considered a risk factor to develop GERD. However, the association between AR and GERD is not clear. We tried to investigate whether AR could increase the development of GERD. Methods: Children diagnosed as AR without a prior history of GERD were conducted from the National Health Insurance Research Database between 2000 and 2005. After propensity score matching, we enrolled 36,588 children with AR and 36,588 non-AR children as the controls. Cox regression models were adopted to calculate the hazard ratio (HR) of GERD. Results: AR children had a significantly increased risk of GERD than non-AR children (adjusted HR 1.91, 95% CI = 1.73-2.11, p < 0.001), especially in the age less than 6 years old (adjusted HR 2.68, 95% CI = 1.64-4.38, p < 0.001). The risk factor related to increased risk of GERD including age, gender, and chronic sinusitis. Conclusion: AR is a risk factor associated with the development of GERD in children. Copyright 2020, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
URI:	http://dx.doi.org/10.1016/j.jmii.2020.08.008 https://www.webofscience.com/wos/woscc/full-record/WOS:000731577700021 https://ir.csmu.edu.tw:8080/handle/310902500/23581
Relation:	JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION ,2021,v54,issue 6, P1167-1174
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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