Neurodevelopment of preterm infants with glucose and sodium abnormalities

doi:10.1016/j.pedneo.2021.06.008

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23566

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23566

Title:	Neurodevelopment of preterm infants with glucose and sodium abnormalities
Authors:	Yang, HY;Lee, CH;Chen, HN;Tsao, LY;Chen, JY;Chang, YJ;Hsiao, CC
Keywords:	glucose;neurodevelopmental disorders;preterm infants;sodium;very low birth weight
Date:	2021
Issue Date:	2022-08-05T09:39:21Z (UTC)
Publisher:	ELSEVIER TAIWAN
ISSN:	1875-9572
Abstract:	Background: Blood glucose and serum sodium abnormalities in very low birth weight infants may cause increased morbidity and mortality, but data regarding the long-term outcomes are limited. This study aimed to investigate the association between the peak and nadir blood glucose and serum sodium levels and neurodevelopmental outcomes in very low birth weight infants. Methods: A single-center retrospective medical record of 284 infants with birth weight<1500 g born between February 1, 2011 and January 31, 2015 was reviewed. We analyzed the correla-tion between peak and nadir blood glucose and serum sodium levels during hospitalization and Bayley Scales of Infant and Toddler Development, third edition at 6, 12, and 24 months of cor-rected age. Results: A total of 284 very low birth weight premature infants were eligible, and 223, 208, and 188 patients were assessed at 6, 12, and 24 months of corrected age, respectively. Multiple linear regression analysis with generalized estimating equations showed that the BSID-III cogni-tive scores were significantly lower in the peak serum sodium group when sodium was S150 mmol/L (95% confidence interval-11.681 to-0.822) than when sodium did not exceed 150 mmol/L. Conclusion: A peak serum sodium of S150 mmol/L is associated with poor cognitive outcomes in very low birth weight infants. Further studies are necessary to determine if this association is causal or an expression of disease severity. Copyright 2021, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/).
URI:	http://dx.doi.org/10.1016/j.pedneo.2021.06.008 https://www.webofscience.com/wos/woscc/full-record/WOS:000714436200010 https://ir.csmu.edu.tw:8080/handle/310902500/23566
Relation:	PEDIATRICS AND NEONATOLOGY ,2021,v62,issue 6, P647-654
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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