Contribution of Interleukin-10 Genotype to Triple Negative Breast Cancer Risk

doi:10.21873/anticanres.15020

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23554

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题名:	Contribution of Interleukin-10 Genotype to Triple Negative Breast Cancer Risk
作者:	Chen, KY;Chien, WC;Liao, JM;Tsai, CW;Chang, WS;Su, CH;Hsu, SW;Wang, HC;Bau, DT
关键词:	Breast cancer;genotype;interleukin-10;polymorphism;Taiwan
日期:	2021
上传时间:	2022-08-05T09:39:09Z (UTC)
出版者:	INT INST ANTICANCER RESEARCH
ISSN:	0250-7005
摘要:	Background/Aim: Triple negative breast cancer (TNBC) is characterized by increased recurrence and poor survival. Mounting evidence suggests that interleukin-10 (IL-10) plays a role in carcinogenesis, however, little is known about the contribution of IL-10 to TNBC. The study evaluated the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genotypes to the risk of TNBC. Materials and Methods: IL-10 genotypes were examined among 1,232 breast cancer patients and 1,232 controls and evaluated. Results: The percentages of AG and GG for IL-10 A 1082G genotypes were higher in the breast cancer patient group than in the control group. The GG genotype carriers were of higher risk for breast cancer [odds ratio (OR)=2.02, 95% confidence interval (CI)=1.28-3.21, p=0.0021]. Interestingly, G allele carriers were of higher risk of TNBC (OR=1.25, 95%CI=1.07-1.46, p=0.0050). Conclusion: The G allele of IL 10 A-1082G genotype may serve as a predictor for TNBC risk. The finding should be validated in other populations.
URI:	http://dx.doi.org/10.21873/anticanres.15020 https://www.webofscience.com/wos/woscc/full-record/WOS:000648665800012 https://ir.csmu.edu.tw:8080/handle/310902500/23554
關聯:	ANTICANCER RESEARCH ,2021,v41,issue 5, P2451-2457
显示于类别:	[中山醫學大學研究成果] 期刊論文

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