Genetic Variants of lncRNA GAS5 Are Associated with the Clinicopathologic Development of Oral Cancer

doi:10.3390/jpm11050348

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23549

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23549

Title:	Genetic Variants of lncRNA GAS5 Are Associated with the Clinicopathologic Development of Oral Cancer
Authors:	Hsieh, MH;Lu, HJ;Lin, CW;Lee, CY;Yang, SJ;Wu, PH;Chen, MK;Yang, SF
Keywords:	growth arrest-specific 5;single nucleotide polymorphism;oral cancer;cell differentiation;tumor stage
Date:	2021
Issue Date:	2022-08-05T09:39:04Z (UTC)
Publisher:	MDPI
Abstract:	The long noncoding RNA, Growth arrest-specific 5 (GAS5) plays a crucial role in the development of oral cancer. However, potential genetic variants in GAS5 that affect the susceptibility and progression of oral cancer have rarely been explored. In this study, two loci of GAS5 single nucleotide polymorphisms (SNPs) (rs145204276 and rs55829688) were genotyped by using the TaqMan allelic discrimination in 1125 oral cancer patients and 1195 non-oral-cancer individuals. After statistical analyses, the distribution of both the GAS5 SNP rs145204276 and GAS5 SNP rs55829688 frequencies were similar between the study and control groups. However, the patients with GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) showed a higher tendency of moderate to poor cell differentiation of oral cancer (OR: 1.454, 95% CI: 1.041-2.031, p = 0.028). Moreover, the GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) in the non-alcohol-drinking population were associated with significantly advanced tumor stage (OR: 1.500, 95% CI: 1.081-2.081, p = 0.015) and larger tumor size (OR: 1.494, 95% CI: 1.076-2.074, p = 0.016). Furthermore, individuals with the GAS5 SNP rs145204276 variant were associated with a higher expression of GAS5 in the GTEx database (p = 0.002), and the higher GAS5 level was associated with poor cell differentiation, advanced tumor stage and larger tumor size in head and neck squamous cell carcinoma from the TCGA database (all p < 0.05). In conclusion, the GAS5 SNP rs145204276 variant is related to poor-differentiation cell status in oral cancer. Besides, the presence of the GAS5 SNP rs145204276 variant is associated with a worse tumor stage and tumor size in oral cancer patients without alcohol drinking.
URI:	http://dx.doi.org/10.3390/jpm11050348 https://www.webofscience.com/wos/woscc/full-record/WOS:000654316500001 https://ir.csmu.edu.tw:8080/handle/310902500/23549
Relation:	JOURNAL OF PERSONALIZED MEDICINE ,2021,v11,issue 5
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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