Analysis of TRIM21 Genetic Variants on the Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma

doi:10.3390/pr9030495

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23453

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23453

Title:	Analysis of TRIM21 Genetic Variants on the Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma
Authors:	Lee, HL;Chien, YC;Chiang, WL;Wang, HL;Hsueh, KC;Chen, CH;Chen, SC;Wu, TK;Pan, YR;Bai, LY;Yang, SF;Yu, YL
Keywords:	tripartite motif 21 (TRIM21);hepatocellular carcinoma (HCC);single nucleotide polymorphism (SNP)
Date:	2021
Issue Date:	2022-08-05T09:37:32Z (UTC)
Publisher:	MDPI
Abstract:	Featured Application: TRIM21 genetic variations may contribute to cancer susceptibility and distant metastasis with HCC patients. Tripartite motif 21 (TRIM21) plays an important role in hepatocellular carcinoma (HCC). However, the gene polymorphisms of TRIM21 in HCC is not as well known. In this study, two single nucleotide polymorphisms (SNPs) in the TRIM21 gene, rs4144331, and re915956, were selected to investigate correlations between these SNPs and susceptibility to HCC. Two SNPs of the TRIM21 gene from 1196 controls without cancer and 394 HCC patients were analyzed using real-time polymerase chain reaction. These results were further analyzed to expound the associations between these TRIM21 polymorphisms and the risk of HCC as well as the impact of these SNPs on clinicopathological characteristics of HCC. After adjustment for other covariants, we observed that that younger patients (<65 years) with the TRIM21 rs915956 A allele had a probability of HCC (AOR = 3.153, 95% CI: 1.315-7.516, p = 0.010). Moreover, patients with a smoking habit who carried the T allele of rs4144331 had more probability of HCC (AOR = 2.940, 95% CI: 1.331-6.491, p = 0.008). In addition, we observed that the polymorphic T allele of rs4144331 led to distant metastasis. Thus, our findings suggest that genetic variations in TRIM21 may correlate to HCC and evaluate distant metastasis in patients with HCC.
URI:	http://dx.doi.org/10.3390/pr9030495 https://www.webofscience.com/wos/woscc/full-record/WOS:000634181000001 https://ir.csmu.edu.tw:8080/handle/310902500/23453
Relation:	PROCESSES ,2021,v9,issue 3
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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