Improvement of Bacterial Vaginosis by Oral Lactobacillus Supplement: A Randomized, Double-Blinded Trial

doi:10.3390/app11030902

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23435

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23435

Title:	Improvement of Bacterial Vaginosis by Oral Lactobacillus Supplement: A Randomized, Double-Blinded Trial
Authors:	Lin, TC;Hsu, IL;Tsai, WH;Chu, YC;Kuan, LC;Huang, MS;Yeh, WL;Chen, YH;Hsu, SJ;Chang, WW
Keywords:	bacterial vaginosis;Lactobacillus;probiotics
Date:	2021
Issue Date:	2022-08-05T09:37:16Z (UTC)
Publisher:	MDPI
Abstract:	Featured Application VGA-1, a combination formula of GMNL Lactobacillus strains, shows improvement effects in bacterial vaginosis (BV) patients and it can potentially be used for BV intervention as a single agent or in combination with the current antibiotics. Bacterial vaginosis (BV) is the most common vaginal infection globally, with a high recurrent rate after antibiotic treatment. Probiotics consumption is known to improve BV with different efficacy among species or strains. After in vitro selection of Lactobacillus strains with growth inhibition and preventing adhesion to HeLa cervical epithelial cells, a randomized and double-blinded trial of two Lactobacillus formula, namely, VGA-1 and VGA-2, in BV patients with Nugent scores of 4-10 was conducted. Among 37 subjects who completed the trial, we observed significantly decreased Nugent scores in both VGA-1 (n = 18) and VGA-2 (n = 19) consumption groups. VGA-1 consumption significantly improved vaginal discharge odor/color and itching at both 2-week and 4-week-consumption, but those only observed after a 4-week-consumption in the VGA-2 group. We also observed a tendency to reduce recurrent rates among enrolled participants after VGA-1 or VGA-2 consumption. The improvement effect of VGA-1/VGA-2 was associated with the significant reduction of interleukin-6 expression after 4-week-consumption and the restoration of normal vaginal microflora by quantitative polymerase chain reaction analysis. In conclusion, VGA-1 or VGA-2 displayed beneficial effects in BV patients, but the VGA-1 formula showed a better efficacy, potentially used for BV intervention.
URI:	http://dx.doi.org/10.3390/app11030902 https://www.webofscience.com/wos/woscc/full-record/WOS:000615012000001 https://ir.csmu.edu.tw:8080/handle/310902500/23435
Relation:	APPLIED SCIENCES-BASEL ,2021,v11,issue 3
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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