Ixekizumab Improves Functioning and Health in the Treatment of Radiographic Axial Spondyloarthritis: Week 52 Results from 2 Pivotal Studies

doi:10.3899/jrheum.200093

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23422

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23422

Title:	Ixekizumab Improves Functioning and Health in the Treatment of Radiographic Axial Spondyloarthritis: Week 52 Results from 2 Pivotal Studies
Authors:	Kiltz, U;Wei, JCC;van der Heijde, D;van den Bosch, F;Walsh, JA;Boonen, A;Gensler, LS;Hunter, T;Carlier, H;Dong, Y;Li, XQ;Bolce, R;Strand, V;Braun, J
Keywords:	ankylosing spondylitis;ASAS Health Index;EQ-5D;ixekizumab;radiographic axial spondyloarthritis;SF-36
Date:	2021
Issue Date:	2022-08-05T09:37:01Z (UTC)
Publisher:	J RHEUMATOL PUBL CO
ISSN:	0315-162X
Abstract:	Objective. This study evaluated the effect of ixekizumab (IXE) on self-reported functioning and health in patients with radiographic axial spondyloarthritis (r-axSpA) who were either biological disease-modifying antirheumatic drug (bDMARD)-naive or failed at least 1 tumor necrosis factor inhibitor (TNFi). Methods. In 2 multicenter, randomized, double-blind, placebo-controlled, and active-controlled (bDMARD-naive only) trials, patients with r-axSpA were randomly assigned to receive 80 mg of IXE [every 2 weeks (Q2W) or every 4 weeks (Q4W)], placebo (PBO), or adalimumab (ADA; bDMARD-naive only). After 16 weeks, patients who received PBO or ADA were rerandomized to receive IXE (Q2W or Q4W) up to Week 52. Functioning and health were measured by the generic 36-item Short Form Health Survey (SF-36) and the disease-specific Assessment of Spondyloarthritis international Society Health Index (ASAS HI). Societal health utility was assessed by the 5-level EuroQol-5 Dimension (EQ-5D-5L). Results. At Week 16, both doses of IXE in bDMARD-naive and TNFi-experienced patients resulted in larger improvement in SF-36, ASAS HI, and EQ-5D-5L versus placcbo. For SF-36, the largest improvements were seen for the domains of bodily pain, physical function, and role physical. A larger proportion of patients reaching improvement in ASAS HI >= 3 as well as an achievement of ASAS HI good health status was reported in patients treated with IXE. Improvements were maintained through Week 52. Conclusion. IXE significantly improved functioning and health as assessed by both generic and disease-specific measures, as well as societal health utility values in patients with r-axSpA, as measured by SF-36, ASAS HI, and EQ-5D-5L at Week 16, and improvements were sustained through 52 weeks.
URI:	http://dx.doi.org/10.3899/jrheum.200093 https://www.webofscience.com/wos/woscc/full-record/WOS:000658215000007 https://ir.csmu.edu.tw:8080/handle/310902500/23422
Relation:	JOURNAL OF RHEUMATOLOGY ,2021,v48,issue 2, P188-197
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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