Impact of tumor disappearance ratio on the prognosis of lung adenocarcinoma <= 2 cm in size: A retrospective cohort study

doi:10.1016/j.jfma.2020.08.024

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23420

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23420

Title:	Impact of tumor disappearance ratio on the prognosis of lung adenocarcinoma <= 2 cm in size: A retrospective cohort study
Authors:	Wu, JJ;Wu, CY;Wu, CY;Wang, CL;Yang, TY;Tseng, JS;Hsu, KH;Huang, YH;Hsu, CP;Chuang, CY;Lin, CH;Tseng, CH;Chen, KC;Chang, GC
Keywords:	Adenocarcinoma subtypes;Lung cancer;Lymph node involvement;Prognosis;Solid part
Date:	2021
Issue Date:	2022-08-05T09:36:59Z (UTC)
Publisher:	ELSEVIER TAIWAN
ISSN:	0929-6646
Abstract:	Background/Purpose: Lung cancer patients can have advanced-stages at diagnosis, even the tumor size is <= 2 cm. We aimed to study the relationship between image characteristics, clinical, and patholoigcal results. Methods: We retrospectively enrolled patients with lung adenocarcinoma at Taichung Veterans General Hospital and Chang Gung Memorial Hospital from 2007 to 2015, who were diagnosed with treatment naive primary tumor lesions at sizes less than 2 cm, as measured by computed tomography (CT) scans. The patient was analyzed for lymph node (LN) and distant metastasis evaluation, with clinicopathological characteristics, including tumor-disappearance ratio (TDR) (tumor diameter at the mediastinal/lung window) over chest CT scans, pathological diagnosis, disease-free survival (DFS), and overall survival (OS). Results: Totally 280 patients were surveyed initially and showed significantly increase of clinical LN involvement and distant metastasis when TDR <= 75% compared with >75% (21.6% vs 0% for LN involvement; 27.1% vs 0% for distant metastasis; both p < 0.001). We included 199 patients having surgical treatment and follow-up for the survival analysis. With a TDR <= 75%, significantly worse DFS (HR, 19.23; 95% CI, 2.60-142.01; p = 0.004) and a trend of worse OS (HR, 4.97; 95% CI, 0.61-40.61; p = 0.134) were noted by Kaplan-Meier method. TDR <= 75% revealed more advanced pathological stage, and more tumors containing micropapillary or solid subtypes when diagnosed adenocarcinoma. Conclusion: For lung cancer patients with primary tumor <= 2 cm, TDR <= 75% was related to more advanced stages, the presence of micropapillary or solid components of adenocarcinoma subtypes, worse DFS, and a trend of worse OS. Copyright (C) 2020, Formosan Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI:	http://dx.doi.org/10.1016/j.jfma.2020.08.024 https://www.webofscience.com/wos/woscc/full-record/WOS:000616271400011 https://ir.csmu.edu.tw:8080/handle/310902500/23420
Relation:	JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION ,2021,v120,issue 2, P874-882
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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