The prevalence and clinical features of chronic obstructive pulmonary disease patients with traits of asthma in Taiwan

doi:10.1016/j.jfma.2021.01.003

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23378

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23378

Title:	The prevalence and clinical features of chronic obstructive pulmonary disease patients with traits of asthma in Taiwan
Authors:	Huang, WC;Sheu, CC;Hsu, JY;Perng, DW;Wang, HC;Cheng, SL;Chen, BP
Keywords:	Clinical practice;COPD;GINA;GOLD guidelines;Traits of asthma
Date:	2021
Issue Date:	2022-08-05T09:36:18Z (UTC)
Publisher:	ELSEVIER TAIWAN
ISSN:	0929-6646
Abstract:	Background/Purpose: The application of the checkbox for identifying patients with traits of both chronic obstructive pulmonary disease (COPD) and asthma proposed by the 2015 Global Initiative for Asthma (GINA)/Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommendations has not been well studied although such identification is important in clinical practice. Thus, we aimed to investigate the prevalence and features of COPD coexistent with asthma traits diagnosed based on the 2015 GINA/GOLD strategies, and explore the gap between guidelines and routine practice in the diagnosis and pharmacological management of such condition in a COPD cohort. Methods: COPD subjects were enrolled retrospectively throughout Taiwan. A patient record form was completed for each participant and the data were analyzed. Results: Of 340 participants, the prevalence of COPD coexistent with traits of asthma was 39.4% and 30.3% based on guidelines and physician's judgment, respectively. Coexistent patients were characterized by blood eosinophilia, higher total immunoglobulin E (IgE) levels, preserved lung function, and the presence of gastro-esophageal reflux disease and atopic disease while total IgE level > 100 kU/L and the presence of atopic disease were predictors for coexistent patients. Gaps existed in the diagnosis (a weak agreement with kappa Z 0.53) and treatment (non-adherence to the preferred therapy in 18.4% of physician-judged coexistent patients) in COPD patients with asthma traits. The exacerbation history was similar between coexistent and non-coexistent patients. Conclusion: We found that measuring circulatory eosinophil and total IgE levels may raise clinicians' awareness of the presence of traits of asthma in the management of COPD. Copyright 2021, Formosan Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
URI:	http://dx.doi.org/10.1016/j.jfma.2021.01.003 https://www.webofscience.com/wos/woscc/full-record/WOS:000732498800004 https://ir.csmu.edu.tw:8080/handle/310902500/23378
Relation:	JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION ,2022,v121,issue 1, P25-35
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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