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https://ir.csmu.edu.tw:8080/ir/handle/310902500/23371
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Title: | Higher CD4/CD8 ratio of pleural effusion predicts better survival for lung cancer patients receiving immune checkpoint inhibitors |
Authors: | Lee, PH;Yang, TY;Chen, KC;Huang, YH;Jeng-Sen Tseng;Hsu, KH;Wu, YC;Liu, KJ;Chang, GC |
Date: | 2021 |
Issue Date: | 2022-08-05T09:36:12Z (UTC)
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Publisher: | NATURE RESEARCH |
ISSN: | 2045-2322 |
Abstract: | Pleural effusion is a rare immune-related adverse event for lung cancer patients receiving immune checkpoint inhibitors (ICIs). We enrolled 281 lung cancer patients treated with ICIs and 17 were analyzed. We categorized the formation of pleural effusion into 3 patterns: type 1, rapid and massive; type 2, slow and indolent; and type 3, with disease progression. CD4/CD8 ratio of 1.93 was selected as the cutoff threshold to predict survival. Most patients of types 1 and 2 effusions possessed pleural effusion with CD4/CD8 ratios >= 1.93. The median OS time in type 1, 2, and 3 patients were not reached, 24.8, and 2.6 months, respectively. The median PFS time in type 1, 2, and 3 patients were 35.5, 30.2, and 1.4 months, respectively. The median OS for the group with pleural effusion CD4/CD8 >= 1.93 and<1.93 were not reached and 2.6 months. The median PFS of those with pleural effusion CD4/CD8<greater than or equal to>1.93 and<1.93 were 18.4 and 1.2 months. In conclusion, patients with type 1 and 2 effusion patterns had better survival than those with type 3. Type 1 might be interpreted as pseudoprogression of malignant pleural effusion. CD4/CD8 ratio<greater than or equal to>1.93 in pleural effusion is a good predicting factor for PFS. |
URI: | http://dx.doi.org/10.1038/s41598-021-89043-4 https://www.webofscience.com/wos/woscc/full-record/WOS:000656499000002 https://ir.csmu.edu.tw:8080/handle/310902500/23371 |
Relation: | SCIENTIFIC REPORTS ,2021,v11,issue 1 |
Appears in Collections: | [中山醫學大學研究成果] 期刊論文
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