Uveitis as a potential predictor of acute myocardial infarction in patients with Behcet's disease: a population-based cohort study

doi:10.1136/bmjopen-2020-042201

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23365

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题名:	Uveitis as a potential predictor of acute myocardial infarction in patients with Behcet's disease: a population-based cohort study
作者:	Chen, YY;Lai, YJ;Yen, YF;Chen, HH;Chou, P
关键词:	myocardial infarction;rheumatology;medical ophthalmology;epidemiology
日期:	2021
上传时间:	2022-08-05T09:36:06Z (UTC)
出版者:	BMJ PUBLISHING GROUP
ISSN:	2044-6055
摘要:	Objectives To investigate whether uveitis is a predictor of acute myocardial infarction (AMI) among patients with Behcet's disease (BD). Design Retrospective cohort study. Setting Patients with BD were retrieved from the whole population of the Taiwan National Health Insurance Research Database from 1 January 2001 to 31 December 2013. Participants Among the 6508 patients with BD, 2517 (38.7%) were in the uveitis group and 3991 were in the non-uveitis group. Primary and secondary outcome measures Kaplan-Meier curves were generated to compare the cumulative hazard of AMI in the uveitis and non-uveitis groups. Multivariate Cox regression analysis was used to estimate the adjusted HRs and 95% CI of AMI, and was adjusted for age, gender, systemic comorbidities (eg, hypertension, diabetes, hyperlipidaemia, smoking) and clinical manifestation of BD (eg, oral ulcers, genital ulcers, skin lesions, arthritis and gastrointestinal involvement). Results The mean age of the BD cohort was 38.1 +/- 15.1 years. Compared with non-uveitis patients, uveitis patients were significantly younger and male predominant. There was no significant difference between the two groups for most proportions of systemic comorbidities and clinical manifestations. The Kaplan-Meier method with the log-rank test showed that the uveitis group had a significantly higher cumulative hazard for patients with AMI compared with the non-uveitis group (p<0.0001). In the multivariable Cox regression after adjustment for confounding factors, patients with uveitis had a significantly higher risk of AMI (adjusted HR 1.87; 95% CI 1.52 to 2.29). Other significant risk factors for AMI were age, hypertension, smoking, and skin lesions. Conclusions Statistical analyses from the nationwide database demonstrated that uveitis is a potential predictor of AMI in patients with BD.
URI:	http://dx.doi.org/10.1136/bmjopen-2020-042201 https://www.webofscience.com/wos/woscc/full-record/WOS:000611963800002 https://ir.csmu.edu.tw:8080/handle/310902500/23365
關聯:	BMJ OPEN ,2021,v11,issue 1
显示于类别:	[中山醫學大學研究成果] 期刊論文

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