|
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 17938/22957 (78%)
Visitors : 7395093
Online Users : 265
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/23352
|
Title: | Oral microbial dysbiosis and its performance in predicting oral cancer |
Authors: | Su, SC;Chang, LC;Huang, HD;Peng, CY;Chuang, CY;Chen, YT;Lu, MY;Chiu, YW;Chen, PY;Yang, SF |
Date: | 2021 |
Issue Date: | 2022-08-05T09:35:53Z (UTC)
|
Publisher: | OXFORD UNIV PRESS |
ISSN: | 0143-3334 |
Abstract: | Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking and betel quid chewing) and individuals' oral health condition. To characterize the disturbances in the oral microbial population mainly due to oral tumorigenicity, we profiled the bacteria within the surface of OSCC lesion and its contralateral normal tissue from discovery (n = 74) and validation (n = 42) cohorts of male patients with cancers of the buccal mucosa. Significant alterations in the bacterial diversity and relative abundance of specific oral microbiota (most profoundly, an enrichment for genus Fusobacterium and the loss of genus Streptococcus in the tumor sites) were identified. Functional prediction of oral microbiome shown that microbial genes related to the metabolism of terpenoids and polyketides were differentially enriched between the control and tumor groups, indicating a functional role of oral microbiome in formulating a tumor microenvironment via attenuated biosynthesis of secondary metabolites with anticancer effects. Furthermore, the vast majority of microbial signatures detected in the discovery cohort was generalized well to the independent validation cohort, and the clinical validity of these OSCC-associated microbes was observed and successfully replicated. Overall, our analyses reveal signatures (a profusion of Fusobacterium nudeatum CTI-2 and a decrease in Streptococcus pneumoniae) and functions (decreased production of tumor-suppressive metabolites) of oral microbiota related to oral cancer. |
URI: | http://dx.doi.org/10.1093/carcin/bgaa062 https://www.webofscience.com/wos/woscc/full-record/WOS:000618630800014 https://ir.csmu.edu.tw:8080/handle/310902500/23352 |
Relation: | CARCINOGENESIS ,2021,v42,issue 1, P127-135 |
Appears in Collections: | [中山醫學大學研究成果] 期刊論文
|
Files in This Item:
File |
Description |
Size | Format | |
index.html | | 0Kb | HTML | 177 | View/Open |
|
All items in CSMUIR are protected by copyright, with all rights reserved.
|