Country-based Comparison of Atrial Fibrillation Patients' Preferences for Oral Anticoagulation: An Evaluation of Discrete Choice Experiments in Five Different Countries

doi:10.1097/FJC.0000000000000936

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23325

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23325

Title:	Country-based Comparison of Atrial Fibrillation Patients' Preferences for Oral Anticoagulation: An Evaluation of Discrete Choice Experiments in Five Different Countries
Authors:	Henry, M;Wosnitza, M;Thate-Waschke, IM;Bauersachs, R;Ueng, KC;Chang, KC;Wilke, T
Keywords:	atrial fibrillation;discrete choice experiment
Date:	2021
Issue Date:	2022-08-05T09:35:26Z (UTC)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
ISSN:	0160-2446
Abstract:	The aim of this study was to examine atrial fibrillation (AF) patients' preferences regarding oral anticoagulation (OAC) characteristics and to investigate differences across 5 different countries. A multicenter discrete choice experiment was conducted in Germany, Sweden, Switzerland, Spain, and Taiwan. Study sites enrolled patients with nonvalvular AF who received continuous OAC therapy. The discrete choice experiment design considered the following 4 attributes with 2 attribute levels each: need for bridging (yes/no), interactions with food/alcohol (yes/no), need for regular international normalized ratio (INR) assessments, and frequency of intake (once/twice daily). Generally, patients (n = 1391) preferred treatment alternatives that were characterized by no need of bridging, no need for regular INR controls, no interactions with food/alcohol, and once daily intake. For this desired treatment regimen, patients were willing to accept a substantially higher travel distance/time. German patients with AF were strongly impacted in their hypothetical treatment decision by the frequency of intake (37.5%). Swedish patients on the other hand gave little importance to intake frequency (12.6%). In Switzerland, patients were especially concerned with food/alcohol interactions of the medication (34.7%), whereas this was the least important attribute for Taiwanese patients (18.9%), who ascribed the most homogenous importance to the different treatment attributes overall. In Spain, the need for regular INR assessments especially impacted the patient's treatment decision (31.9%). Patients of all countries attributed a moderate importance to the need for bridging (25.9%-34.2%). These findings may facilitate country-specific consideration of patients' preferences regarding OAC therapy, potentially increasing treatment acceptance on the patient's side with the ultimate goal of improving treatment adherence and persistence.
URI:	http://dx.doi.org/10.1097/FJC.0000000000000936 https://www.webofscience.com/wos/woscc/full-record/WOS:000607339300015 https://ir.csmu.edu.tw:8080/handle/310902500/23325
Relation:	JOURNAL OF CARDIOVASCULAR PHARMACOLOGY ,2021,v77,issue 1, P100-106
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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