Quality validation of platelets obtained from the Haemonetics and Trima Accel automated blood-collection systems

doi:10.1016/j.tracli.2020.10.010

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23319

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23319

Title:	Quality validation of platelets obtained from the Haemonetics and Trima Accel automated blood-collection systems
Authors:	Wang, HH;Liao, LN;Lin, CL;Yen, LL;Hsiao, YM;Ko, JL
Keywords:	Platelet apheresis (PA);Leucocyte-reduced platelets apheresis (LRPA);Platelet qualities;Bacterium-screening test
Date:	2021
Issue Date:	2022-08-05T09:35:21Z (UTC)
Publisher:	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
ISSN:	1246-7820
Abstract:	Background. - Platelet transfusion is required to treat haemo-oncology or trauma patients. Platelet apheresis (PA) performed with apheresis equipment has increased rapidly in recent years. Leucocyte-reduced platelet apheresis (LRPA) can reduce the risk of platelet refractoriness and febrile nonhemolytic transfusion reactions (FNHTRs) for transfusion. Accordingly, this study aimed to investigate and compare the platelet metabolic and functional responses between PA performed with Haemonetics and LRPA performed with Trima Accel cell separator. Methods. - The qualities of platelets collected through PA and LRPA were evaluated in terms of visual appearance, morphology, platelet-aggregation changes, metabolic activities, and bacterium-screening test during 5-day storage. Statistical analyses included two-sample t-test and generalised estimating equation( GEE) method. Results. - During 5-day storage in LRPA, residual leucocytes were all <1.0 x 10(6), and the parameters of platelet function were as follows: platelet aggregated to agonists such as adenosine 5'-diphosphate (ADP) and collagen, and the extent of shape change and p0 2 showed no statistically significant difference between PA and LRPA. The hypotonic shock reaction (HSR) on days 0, 1, and 3 were significantly higher in LRPA than in PA (71.78 +/- 6.92 vs. 64.10 +/- 7.42; P=0.002; 71.53 +/- 8.98 vs. 62.96 +/- 9.84; P=0.007; 68.05 +/- 7.28 vs. 57.76 +/- 6.80; P<0.0001, respectively). Values of mean platelet volume (MPV) were statistically larger in PA than in LRPA on days 0, 1, and 3. On day 5, the swirling score was higher in LRPA than in PA. The mean lactate levels had no statistically significant difference between PA and LRPA. Moreover, no growth was observed through bacterium-screening test conducted on 40 samples. Conclusion. - Comparison of LRPA and PA products collected from the Trima Accel and Haemonetics automated blood-collection systems, respectively, revealed that both products possessed good platelet qualities even though additional processes are needed to reduce leucocytes. Furthermore, investigating the outcomes of other apheresis instruments with focus on the safety of donors, products, and recipients is necessary. (C) 2020 Societe francaise de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved.
URI:	http://dx.doi.org/10.1016/j.tracli.2020.10.010 https://www.webofscience.com/wos/woscc/full-record/WOS:000614182100009 https://ir.csmu.edu.tw:8080/handle/310902500/23319
Relation:	TRANSFUSION CLINIQUE ET BIOLOGIQUE ,2021,v28,issue 1, P44-50
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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