Efficacy and Safety of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate in Asian Subjects with Human Immunodeficiency Virus 1 Infection: A Sub-Analysis of Phase 3 Clinical Trials

doi:doi.org/10.3947/ic.2016.48.3.219

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學研究所 > 期刊論文 > Item 310902500/22203

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/22203

Title:	Efficacy and Safety of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate in Asian Subjects with Human Immunodeficiency Virus 1 Infection: A Sub-Analysis of Phase 3 Clinical Trials
Authors:	Choi, Jun Yong Sungkanuparph, Somnuek Anekthananon, Thanomsak Sax, Paul DeJesus, Edwin Edelstein, Howard Nelson, Mark DeMorin, Jennifer Liu, Hui C Swamy, Raji Bahn, Joonwoo Hwang, Sunjin Yang, Sang Youn Ng, Christopher Piontkowsky, David
Contributors:	中山醫學大學;醫研所
Keywords:	Antiretroviral therapy;Asian Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate;Human immunodeficiency virus.
Date:	2016-09
Issue Date:	2022-03-29T03:26:59Z (UTC)
ISSN:	2093-2340
Abstract:	The efficacy and safety of a single tablet regimen (STR) of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (E/C/F/TDF) were analyzed in Phase 3 clinical trials in antiretroviral therapy (ART)-naïve and ART-experienced Asian subjects infected with human immunodeficiency virus (HIV)-1. Studies GS-US-236-102 and GS-US-236-103 were randomized, double-blind, placebo-controlled, 144-week studies conducted in ART-naïve subjects, comparing E/C/F/TDF versus efavirenz (EFV)/F/TDF or ritonavir-boosted atazanavir (ATV+RTV) plus emtricitabine/tenofovir DF (F/TDF), respectively. Studies GS-US-236-115 and GS-US-236-121 were randomized, open-label, 96-week long conducted in ART-experienced subjects, who switched to E/C/F/TDF from ritonavir-boosted protease inhibitors (PI+RTV)+F/TDF, or non-nucleoside reverse transcriptase inhibitors (NNRTI)+F/TDF regimens. The E/C/F/TDF appeared to have sustained efficacy and safety and was well tolerated in the small number of ART-naïve and ART-experienced Asian subjects.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/22203
Relation:	Infect Chemother, 48(3), 219-224
Appears in Collections:	[醫學研究所] 期刊論文

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