中山醫學大學機構典藏 CSMUIR:Item 310902500/21631
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    题名: High SPOCK1 Expression Is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer
    作者: Mei-Ling Chen;Cheng-Ju Ho;Chung-Min Yeh;Sung-Lang Chen;Wen-Wei Sung;Shao-Chuan Wang;Chih-Jung Chen
    关键词: SPOCK1;prostate cancer;Gleason grade;survival
    日期: 2019-07-05
    上传时间: 2021-08-17T02:33:11Z (UTC)
    出版者: MDPI
    摘要: Background and objectives: Prostate cancer (PCa) is a common malignancy in males and has a relatively slower progression than other cancers. Our goal was to evaluate the clinical role of SPARC (secreted protein acidic and cysteine rich, osteonectin), cwcv, and kazal-like domains’ proteoglycan 1 (SPOCK1) in PCa. Materials and Methods: SPOCK1 expression was studied through the immunohistochemical staining of specimens from 71 patients with PCa. The correlation between SPOCK1 expression and clinicopathological features was quantitatively analyzed. We used Kaplan–Meier analysis and Cox proportional hazard models to analyze the prognostic value. Results: Of 71 PCa patients, high SPOCK1 expression was more likely to be seen in those with an advanced stage (p = 0.018) of the disease and an advanced tumor (T) value (p = 0.014). Patients in Gleason grade groups 3 and 4 had significantly higher SPOCK1 expression (p = 0.044 and 0.003, respectively) compared to those of Gleason grade group 1. However, this trend was not observed in patients in Gleason grade group 5. For the survival analysis, although it was not statistically significant, patients with a high SPOCK1 expression had a shorter median overall survival (6.2 years) compared to those with low expression (7.8 years). Conclusions: High SPOCK1 expression may be related to advanced clinicopathological features and possibly a poor prognosis. Further analysis with a larger patient base would help clarify this issue.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/21631
    關聯: Medicina 2019, 55(7), 343
    显示于类别:[醫學系] 期刊論文

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