中山醫學大學機構典藏 CSMUIR:Item 310902500/20208
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    题名: Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence
    作者: Yang, Po-Yu
    Miao, Nae-Fang
    Lin, Chiao-Wen
    Chou, Ying-Erh
    Yang, Shun-Fa
    Huang, Hui-Chuan
    Chang, Hsiu-Ju
    Tsai, Hsiu-Ting
    贡献者: 中山醫學大學口腔醫學研究所
    关键词: Alcohol consumption;Genetic polymorphism;Environmental impacts;Cancer risk factors;Alleles;Genetic predisposition;Apoptosis;Polymerase chain reaction
    日期: 2016-08
    上传时间: 2019-05-31T04:17:02Z (UTC)
    出版者: PLoS One
    ISSN: 1932-6203
    摘要: Background
    The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status.

    Methodology/Principal Findings
    Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption.

    Conclusion
    G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/20208
    關聯: PLoS One. 2016; 11(8): e0160841
    显示于类别:[口腔醫學研究所] 期刊論文

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