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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/19903
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Title: | A new avenue for treating neuronal diseases: Ceftriaxone, an old antibiotic demonstrating behavioral neuronal effects |
Authors: | Chen, A.-C. Lin, C.-L. Li, H.-H. Lin, P.-J. Liao, W.-C. |
Contributors: | 圖書館 |
Date: | 2019-03 |
Issue Date: | 2019-03-12T03:45:33Z (UTC)
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ISSN: | 01664328 |
Abstract: | Several neurodegenerative disorders, namely Parkinson's disease dementia, dementia with Lewy bodies, and Alzheimer's disease, share common pathophysiological features, such as (1) cognitive deficits, (2) glutamatergic hyperactivity-related excitotoxicity, and (3) deposition of α-synuclein (α-syn) and β-amyloid (Aβ). Ceftriaxone (CEF) is a well-tested and safe drug that has been used as an antibiotic for several decades. Recent studies have demonstrated the following effects of CEF: (1) increasing glutamate transporter-1 expression and glutamate reuptake and suppressing excitotoxicity, (2) binding well with α-syn and inhibition of α-syn polymerization, (3) modulating expression of genes related to Aβ metabolism, and (4) enhancing neurogenesis and recovery of neuronal density. In addition, our data revealed that CEF ameliorates seizure and abnormal neuronal firing in the brain. These results suggest the potential of CEF in treating neuronal disorders. This paper addresses the effects and pharmacology of CEF. © 2019 Elsevier B.V. |
URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/19903 |
Relation: | Behavioural Brain Research Volume 364, 17 May 2019, Pages 149-156 |
Appears in Collections: | [心理學系暨臨床心理學暨碩士班] 期刊論文
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