中山醫學大學機構典藏 CSMUIR:Item 310902500/19405
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    题名: Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks
    作者: Tsai, Hsiu-Ting
    Hsieh, Ming-Ju
    Lin, Chiao-Wen
    Su, Shih-Chi
    Miao, Nae-Fang
    Yang, Shun-Fa
    Huang, Hui-Chuan
    Lai, Fu-Chih
    Liu, Yu-Fan
    贡献者: 中山醫學大學口腔醫學研究所
    日期: 2017-03-24
    上传时间: 2018-10-17T07:28:09Z (UTC)
    ISSN: 1932-6203
    摘要: BACKGROUND:
    We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status.

    METHODOLOGY/PRINCIPAL FINDINGS:
    In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07~2.31 and OR, 1.58; 95% CI, 1.04~2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65~11.01; p = 0.002), 2.34- (95% CI: 1.19~4.61; p = 0.01), and 2.34-fold (95% CI: 1.38~3.96; p = 0.001) higher risks of developing oral cancer.

    CONCLUSIONS:
    Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19405
    關聯: PLoS One. 2017; 12(3): e0163369
    显示于类别:[口腔醫學研究所] 期刊論文

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