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https://ir.csmu.edu.tw:8080/ir/handle/310902500/19405
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| Title: | Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks |
| Authors: | Tsai, Hsiu-Ting
Hsieh, Ming-Ju
Lin, Chiao-Wen
Su, Shih-Chi
Miao, Nae-Fang
Yang, Shun-Fa
Huang, Hui-Chuan
Lai, Fu-Chih
Liu, Yu-Fan |
| Contributors: | 中山醫學大學口腔醫學研究所 |
| Date: | 2017-03-24 |
| Issue Date: | 2018-10-17T07:28:09Z (UTC)
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| ISSN: | 1932-6203 |
| Abstract: | BACKGROUND:
We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status.
METHODOLOGY/PRINCIPAL FINDINGS:
In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07~2.31 and OR, 1.58; 95% CI, 1.04~2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65~11.01; p = 0.002), 2.34- (95% CI: 1.19~4.61; p = 0.01), and 2.34-fold (95% CI: 1.38~3.96; p = 0.001) higher risks of developing oral cancer.
CONCLUSIONS:
Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development. |
| URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/19405 |
| Relation: | PLoS One. 2017; 12(3): e0163369 |
| Appears in Collections: | [口腔醫學研究所] 期刊論文
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