中山醫學大學機構典藏 CSMUIR:Item 310902500/19228
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    题名: Downregulation of miR-1 enhances tumorigenicity and invasiveness in oral squamous cell carcinomas
    作者: CY, Peng
    YW, Liao
    MY, Lu
    CH, Yu
    CC, Yu
    MY, Chou
    贡献者: 中山醫學大學
    关键词: invasiveness;miR-1;oral squamous cell carcinomas
    日期: 2017-10
    上传时间: 2018-06-20T08:57:47Z (UTC)
    出版者: Journal of the Formosan Medical Association
    ISSN: http://dx.doi.org/10.1016/j.jfma.2016.12.003
    0929-6646
    摘要: BACKGROUND/PURPOSE:
    Cumulative evidence suggest that microRNAs (miRNAs) function as biosignatures of oral squamous cell carcinomas (OSCC). However, the functional roles of miR-1 as well as its downstream targets in the regulation of tumorigenicity in OSCC remain unclear.

    METHODS:
    miRNAs RT-PCR analysis was performed to identify miR-1 as a putative candidate on mediating invasiveness of OSCC cells. Consequently, we elucidated the tumorigenicity of OSCC cells with miR-1 downregulation or overexpression, respectively. Finally, miR-1 on OSCC tumor tissues was examined.

    RESULTS:
    miR-1 levels were significantly downregulated in the malignant OSCC cells. Overexpression of miR-1 significantly reduced migration/invasiveness of OSCC cells. In addition, overexpression of miR-1 decreased cancer stem cells properties. Conversely, downregulation of miR-1 promotes migration and invasiveness in OSCC cells. We have shown that miR-1 is able to target Slug, suppressing their expression. Clinically, lower miR-1 expression was found in patients with advanced nodal metastasis OSCC.

    CONCLUSION:
    miR-1 as novel biosignatures in OSCC lymph node metastatic patients, supporting the development of novel strategies for OSCC treatment.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/19228
    關聯: Journal of the Formosan Medical Association, 2017-10-01, 卷 116, 期 10, 頁面 782-789
    显示于类别:[牙醫學系暨碩士班] 博碩士論文

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