中藥方劑豬苓湯對腎性高血壓鼠降壓效果之研究

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题名:	中藥方劑豬苓湯對腎性高血壓鼠降壓效果之研究 Anti-hypertensive Effects of Traditional Chinese Medicine Ju-Ling-Tang on Renal Hypertensive Rats
作者:	李建塋;鄭人豪;蘇清泉;周明勇;乃瑜;施宏哲 Chien-Ying Li;Ren-Hau Jeng;Ching-Chyuan Su;Ming-Yung Chou;Nai-Yu Tu;Hung-Che Shih
贡献者:	中山醫學大學
关键词:	中國傳統藥物;豬苓湯;腎性高血壓 traditional Chinese medicine;Ju-Ling-Tang;renal hypertension
日期:	2003-05-01
上传时间:	2010-07-28T09:04:09Z (UTC)
出版者:	教務處出版組
摘要:	本研究旨在探討中藥方劑豬苓湯對單腎血管結紮腎病變型高血壓之降血壓效果。結果顯示：於自發運動測試項目中，口服豬苓湯 240 mg/kg 之實驗組給藥30分鐘後，其自發運動量(Ambulation數)，較口服給予0.9%NaCI之實驗組為低，口服豬苓湯60mg/kg與120 mg/kg之實驗組其自發運動量較口服240 mg/kg豬苓湯實驗組為高。抗不安作用實驗中，明顯發現給予豬苓湯 240 mg/kg實驗組誘導睡眠的起始時間較給予Sod. pentobarbital(35 mg/kg)之實驗組為短。單腎血管結紮高血壓大鼠口服豬苓湯240 mg/kg經60分鐘後，血壓明顯降低21mmHg(P<0.05)，且降壓作用可維持120分鐘，口服α─Methyldopa 50 mg/kg之對照組動物，經過240分鐘後，出現降壓效果(降幅達34mmHg)。大鼠腦內Monoamine含量變化之測定結果：口服豬苓湯60 mg/kg、120 mg/kg及240 mg/kg，其大腦內皮質部及腦幹部中N E之含量呈現依劑量之增加而有意義之減少(P <0.05)。從病理組織變化之實驗顯示，口服豬苓湯240 mg/kg之實驗動物，對單腎結紮大鼠導致腎絲球的硬化程度有明顯的降低。由以上實驗結果推論豬苓湯對腎病變型之高血壓具有良好降血壓之效果，且其降壓效果與其對中樞神經化學傳導物質有密切的關連性。 The blood pressure-lowering effect of the traditional Chinese medicine Ju-Ling-Tang (JLT) was investigated in a hypertensive rat model using unilateral renal artery ligature. Level of self-ambulation 30 min after administration of JLT (240mg/kg) was less than in controls receiving 0.9% NaCl. Rats that were administered 60 and 120 mg/kg JLT had greater ambulatory activity than rats receiving 240 mg/kg JLT. Regarding anti-anxiety effects, onset time required for sleep induction was shorter for animals given 240 mg/kg JLT than in rats administered 35 mg/kg sodium pentobarbital. JLT (240 mg/kg) significantly prolonged sodium pentobarbital-induced sleep time. Sixty minutes after oral administration of JLT (240mg/kg) to hypertensive rats, blood pressure was significantly lowered by 21 mmHg (p <0.05) for 120 min. Administration of 50 mg/kg α-methyldopa to the control group reduced blood pressure (reaching 34 mmHg) for 240 min. Norepinephrine (NE) measurements in the rat brain indicated that JLT induced a dose-dependent decrease (p < 0.05) in NE concentration within the cerebral cortex and brain stem. In rats that received 240 mg/kg JLT, pathological examination of the kidneys demonstrated a reduction in glomerular sclerosis in rats with ligated renal arteries compared with controls. Our findings suggest that in cases of hypertension caused by renal pathological changes, JLT has an excellent blood pressure-lowering effect that is closely related to effects of neurotransmitters in the central nervous system.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/1910
關聯:	中山醫學雜誌, v14 n.2 p247-257
显示于类别:	[教務處] 期刊論文

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