中山醫學大學機構典藏 CSMUIR:Item 310902500/18991
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18991


    题名: Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent
    作者: Hsu, Ming Fang;Tyan, Yen Sheng;Chien, Yu Chen;Lee, Ming Wei
    贡献者: 中山醫學大學
    日期: 2018-12-01
    上传时间: 2018-03-21T09:50:36Z (UTC)
    出版者: Nature Publishing Group
    ISSN: 20452322
    摘要: The purpose of this study was to develop a gellan gum-based multifunctional embolic agent. Calibrated spherical gellan gum and nanoparticle-containing gellan gum microspheres were prepared via water-in oil emulsification method. Self-assembled nanoparticles composed of short-chain hyaluronic acid and polyethylenimine as the doxorubicin carrier were prepared. The short-chain hyaluronic acid/polyethylenimine/ doxorubicin (sHH/PH/Dox) with the mean size was 140 ± 8 nm. To examine sHH/PH/Dox nanoparticle uptake into cells, the results confirmed that sHH/PH nanoparticles as drug carrier can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, sHH/PH/Dox merged into the gellan gum (GG) microspheres forming GG/sHH/PH/Dox microsphere. After a drug release experiment lasting 45 days, the amount of released doxorubicin from 285, 388, and 481 μm GG/sHH/PH/Dox microspheres were approximately 4.8, 1.8 and 1.1-fold above the IC50 value of the HepG2 cell. GG/sHH/PH/Dox microspheres were performed in rabbit ear embolization model and ischemic necrosis on ear was visible due to the vascular after 8 days. Regarding the application of this device in the future, we aim to provide better embolization agents for transcatheter arterial chemoembolization (TACE). © 2018 The Author(s).
    URI: https://www.doi.org/10.1038/s41598-018-19191-7
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/18991
    關聯: Scientific Reportsvolume 8, Article number: 731 (2018)
    显示于类别:[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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