中山醫學大學機構典藏 CSMUIR:Item 310902500/18562
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    题名: Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease: a clinicopathologic study from nephrectomized kidneys
    作者: Hung, Tung-Wei;Liou, Jia-Hung;Yeh, Kun-Tu;Tsai, Jen-Pi;Wu, Sheng-Wen;Tai, Hui-Chun;Kao, Wei-Tse;Lin, Shu-Hui;Cheng, Ya-Wen;Chang, Horng-Rong
    贡献者: 中山醫大
    关键词: Chronic kidney disease;GFR;hypoxia inducible factor-1α;nephrectomy;renal fibrosis;renal function
    日期: 2013-01
    上传时间: 2017-11-14T08:13:17Z (UTC)
    摘要: Background & objectives:

    Hypoxia inducible factor-1α (HIF-1α) has been shown to play a role in the pathogenesis of renal interstitial fibrosis. However, the relationship of HIF-1α expression intensity in human renal tissue with the degree of renal function or renal fibrosis has not been investigated. We therefore, undertook this study to assess the relationship between HIF-1α expression and degree of renal impairment and renal fibrosis using renal tissue from nephrectomized kidneys from patients with chronic kidney disease.

    Methods:

    This retrospective study was performed with 70 patients undergoing unilateral or bilateral nephrectomy because of renal cell carcinoma, urothelial cell carcinoma, or renal abscess. Immunohistochemical analysis of HIF-1α expression in non-tumourous or non-abscess renal parenchyma was performed. The patients were divided into two groups: group 1 (n=37) with low intensity HIF-1α expression and group 2 (n=33) with high intensity HIF-1α expression.

    Results:

    The intensity of renal HIF-1α expression was significantly associated with serum creatinine level (P=0.005), estimated glomerular filtration rate (P=0.02), fibrosis score of the interstitium (P=0.004) and glomerular sclerosis (P=0.013). A high intensity of HIF-1α expression tended to be associated with lower serum creatinine, higher estimated glomerular filtration rate, low interstitial fibrosis score and low glomerular sclerosis. In addition, multivariate analysis by step-wise logistic regression demonstrated that interstitial fibrosis was the only independent factor associated with the intensity of renal HIF-1α expression (OR 4.107, CI 1.535-11.313, P=0.005).

    Interpretation & conclusions:

    This study demonstrated a correlation between intensity of HIF-1α expression and degree of renal interstitial fibrosis. The association demonstrated an elevated HIF-1α expression in less severe kidney disease. The intensity of HIF-1α renal expression plays a role in the pathogenesis of chronic kidney disease.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18562
    關聯: Indian J Med Res. 2013 Jan; 137(1): 102–110.
    显示于类别:[醫學研究所] 期刊論文

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