Glutathione S-transferase gene polymorphisms are not major risks for susceptibility to posttransplantation diabetes mellitus in Taiwan renal transplant recipients

doi:10.1002/jcla.20498

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學研究所 > 期刊論文 > Item 310902500/18559

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题名:	Glutathione S-transferase gene polymorphisms are not major risks for susceptibility to posttransplantation diabetes mellitus in Taiwan renal transplant recipients
作者:	Tsai, Jen-Pi Yang, Shun-Fa Wu, Sheng-Wen Hung, Tung-Wei Tsai, Hui-Ching Lian, Jong-Da Chang, Horng-Rong
贡献者:	中山醫大
日期:	2011-11-15
上传时间:	2017-11-14T08:02:45Z (UTC)
ISSN:	0887-8013
摘要:	Glutathione S-transferase (GST) M1 null genotype has been reported playing a significant role in the diabetes mellitus (DM) susceptibility in Turkish population. We investigated whether the GSTM1, GSTA1, and GSTP1 gene polymorphisms are associated with posttransplantation diabetes mellitus (PTDM) in Taiwan. There were 283 renal transplant recipients (RTRs) enrolled. Polymerase chain reaction–restriction fragment length polymorphism was used for the measurement of GSTA1, M1, and P1 genetic polymorphisms. PTDM was diagnosed according to the American Diabetes Association guidelines. Eight-five patients (30%) were diagnosed with PTDM. The averaged posttransplant follow-up period was 77.9 ± 27.2 months. Duration from transplantat to diagnosis of PTDM ranged from 0.2 to 103.1 months (19.2 ± 26.3 months). There were significantly differences between non-DM and PTDM groups in age (50.6 ± 11.0 vs. 54.6 ± 9.36 years, P = 0.005), BMI (22.4 ± 3.6 vs. 24.3 ± 3.8, P<0.001). The distributions of GSTA1, GSTP1, and GSTM1 genotypes alleles were not significantly different between PTDM and non-DM group. Patients carrying the different GSTA1, GSTP1, and GSTM1 genetic and allelic polymorphisms had no differences for the development of PTDM. These overall results suggested a lack of strong association with GSTA1, GSTP1, and GSTM1 genetic polymorphisms to the susceptibility of PTDM in Taiwanese RTRs. J. Clin. Lab. Anal. 25:432–435, 2011. © 2011 Wiley Periodicals, Inc.
URI:	http://dx.doi.org/10.1002/jcla.20498 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18559
關聯:	Journal of Clinical Laboratory Analysis Previous article in issue: Detection of α-globin gene deletions using denaturing high-performance liquid chromatography and multiplex ligation-dependent probe amplification View issue TOC Volume 25, Issue 6 November 2011 Pages 432–435
显示于类别:	[醫學研究所] 期刊論文

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