Diagnostic performance of serum cystatin C and serum creatinine in the prediction of chronic kidney disease in renal transplant recipients

doi:10.1016/j.transproceed.2010.09.150

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學研究所 > 期刊論文 > Item 310902500/18558

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题名:	Diagnostic performance of serum cystatin C and serum creatinine in the prediction of chronic kidney disease in renal transplant recipients
作者:	JP, Tsai SW, Wu TW, Hung WT, Kao CL, Hong JD, Lian HR, Chang
贡献者:	中山醫大
日期:	2010-12
上传时间:	2017-11-14T07:58:25Z (UTC)
ISSN:	0041-1345
摘要:	BACKGROUND: Chronic kidney disease (CKD) has adverse impacts on mortality and morbidity of renal transplant recipients. Serum cystatin C (sCysC) is a novel marker in predicting the CKD. We therefore compare sCysC and serum creatinine (sCr) with the aim of improving the detection of CKD in renal transplant recipients. METHODS: We enrolled 106 renal transplant recipients and estimated glomerular filtration rates (GFR) using the Cockcroft-Gault (GFR(CG)) and the abbreviated Modification of Diet in Renal Disease (GFR(aMDRD)) formulae. We defined CKD as the presence of structural or functional kidney damage, irrespective of the diagnosis. Comparisons of sCysC and sCr in detecting CKD were analyzed. RESULTS: sCysC correlates with sCr significantly (r = 0.87; P < .001). The receiver operating characteristic curve demonstrates that sCysC has a better specificity and area under the curve, but less sensitivity than sCr in predicting CKD in renal transplant recipients if GFR is estimated by GFR(CG). Additionally, if GFR was estimated by GFR(aMDRD), the role of sCysC or sCr in prediction of CKD was comparable. CONCLUSION: sCysC may be better than sCr to detect CKD in renal transplant recipients using the GFR(CG).
URI:	http://dx.doi.org/10.1016/j.transproceed.2010.09.150 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18558
關聯:	Transplant Proc. 2010 Dec;42(10):4530-3.
显示于类别:	[醫學研究所] 期刊論文

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