Root canal sealers cause cytotoxicity and oxidative damage in hepatocytes

doi:10.1002/1097-4636(20010305)54:3<390::AID-JBM110>3.0.CO;2-U

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/18292

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18292

题名:	Root canal sealers cause cytotoxicity and oxidative damage in hepatocytes
作者:	Hunag, T.-H.;Lii, C.-K.;Kao, C.-T.
关键词:	Cytotoxicity;Glutathione;LDH leakage;Oxidative stress;Root canal sealer
日期:	2001
上传时间:	2017-08-09T04:45:08Z (UTC)
出版者:	John Wiley & Sons Inc, New York, NY, United States
ISSN:	219304
摘要:	Elutable substances and degradation products from root canal sealers may gain access to periodontal tissue in many ways. The aim of this study was to investigate damage and oxidative stress caused by treatment with root canal sealers in primary cultured rat hepatocytes. Four root canal sealers were used: Canals, Sealapex, AH 26, and AH Plus. Toxicity was detected by assessing lactate dehydrogenase (LDH) leakage, and oxidative stress was determined by analysis of glutathione (GSH) levels. One-way analysis of variance was performed on the data. As the concentrations of sealer were increased, LDH leakage increased (p < 0.01). Increased GSH depletion accompanied LDH leakage increase. GSH levels were reduced to zero at a concentration of 0.05% for Canals and 0.10% for AH 26. These results confirmed the hypothesis that root canal sealers can cause cytotoxicity in hepatocytes. The Canals and AH 26 sealers can also cause oxidative stress in hepatocytes. © 2000 John Wiley & Sons, Inc.Elutable substances and degradation products from root canal sealers may gain access to periodontal tissue in many ways. The aim of this study was to investigate damage and oxidative stress caused by treatment with root canal sealers in primary cultured rat hepatocytes. Four root canal sealers were used: Canals, Sealapex, AH 26, and AH Plus. Toxicity was detected by assessing lactate dehydrogenase (LDH) leakage, and oxidative stress was determined by analysis of glutathione (GSH) levels. One-way analysis of variance was performed on the data. As the concentrations of sealer were increased, LDH leakage increased (p<0.01). Increased GSH depletion accompanied LDH leakage increase. GSH levels were reduced to zero at a concentration of 0.05% for Canals and 0.10% for AH 26. These results confirmed the hypothesis that root canal sealers can cause cytotoxicity in hepatocytes. The Canals and AH 26 sealers can also cause oxidative stress in hepatocytes.
URI:	http://dx.doi.org/10.1002/1097-4636(20010305)54:3<390::AID-JBM110>3.0.CO;2-U https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035809840&doi=10.1002%2f1097-4636%2820010305%2954%3a3%3c390%3a%3aAID-JBM110%3e3.0.CO%3b2-U&partnerID=40&md5=9dba754a9cfc0c249d05072a61acabfb https://ir.csmu.edu.tw:8080/ir/handle/310902500/18292
關聯:	Journal of Biomedical Materials Research 54(3) ,390-395
显示于类别:	[牙醫學系暨碩士班] 期刊論文

文件中的档案:

没有与此文件相关的档案.

在CSMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....