Evaluation of the genotoxicity of zinc oxide eugenol-based, calcium hydroxide-based, and epoxy resin-based root canal sealers by comet assay

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/18289

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Title:	Evaluation of the genotoxicity of zinc oxide eugenol-based, calcium hydroxide-based, and epoxy resin-based root canal sealers by comet assay
Authors:	Kao, C.-T.
Date:	2001
Issue Date:	2017-08-09T04:45:00Z (UTC)
ISSN:	0099-2399
Abstract:	Three main types of root canal sealer are currently commonly used in pulp treatment: zinc oxide eugenol-based, calcium hydroxide-based, and epoxy resin-based sealers. In the present study, the genotoxicity of sealer on oral carcinoma cells was evaluated by single-cell gel electrophoresis assay (comet assay). The whole length of the comet and the diameter of the head were measured using an image analysis system. The results were analyzed by one-way analysis of variance to compare the various means. The zinc oxide eugenol-based sealers (Canals, Canals-N, and Tubilseal) did not always cause a dose-dependent increase in genotoxicity. The resin-based sealers (Topseal, AH 26, and AH Plus) caused a dose-dependent increase in genotoxicity, but no such effect was seen with the calcium hydroxide-based sealer (Sealapex). The highest level of DNA damage was induced by the resin-based sealers. Copyright © 2001 by The American Association of Endodontists.
URI:	http://dx.doi.org/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035654245&partnerID=40&md5=1eb165ee390fafa67909918801fa220f https://ir.csmu.edu.tw:8080/ir/handle/310902500/18289
Relation:	Journal of Endodontics 27(12) ,744-748
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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