The biocompatibility evaluation of epoxy resin-based root canal sealers in vitro

doi:10.1016/S0142-9612(01)00081-3

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/18288

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18288

Title:	The biocompatibility evaluation of epoxy resin-based root canal sealers in vitro
Authors:	Huang, T.-H.;Yang, J.-J.;Li, H.;Kao, C.-T.
Keywords:	Alkaline single cell gel electrophoresis;Biocompatibility of epoxy resin sealer;MTT assay
Date:	2002
Issue Date:	2017-08-09T04:44:58Z (UTC)
ISSN:	1429612
Abstract:	The cytotoxic and mutagenic effects of epoxy resin-based root canal sealer AH26 and AH-Plus were determined in vitro. Root canal sealers were eluted for 24h in dimethyl sulfoxide (DMSO) and diluted in culture medium. Cytotoxic effects were assessed using the MTT [tetrazolium dye, 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide, C18H16N5SBr] assay for mitochondrial enzyme activity and also the cell viability. Genotoxicity assays were assessed using the alkaline single cell gel electrophoresis assay (comet assay) for DNA damage measurement. Result indicated that both the AH26 and AH-Plus sealers exhibited a dose-dependent increase in astrocyte toxic effects. Additionally, dose-dependent astrocyte DNA damage was also noted for both sealers. Therefore, these epoxy resin-based sealers, AH26 and AH-Plus demonstrated both cytotoxicity and genotoxicity in vitro. Copyright © 2001 Elsevier Science Ltd.
URI:	http://dx.doi.org/10.1016/S0142-9612(01)00081-3 https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036027554&doi=10.1016%2fS0142-9612%2801%2900081-3&partnerID=40&md5=f8e5b68987f669484cce9e48f397b914 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18288
Relation:	Biomaterials 23(1) ,77-83
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

Files in This Item:

There are no files associated with this item.

Loading...