The synergistic effects of CO<inf>2</inf> laser treatment with calcium silicate cement of antibacterial, osteogenesis and cementogenesis efficacy

doi:10.1088/1612-2011/12/5/055602

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/18231

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题名:	The synergistic effects of CO2 laser treatment with calcium silicate cement of antibacterial, osteogenesis and cementogenesis efficacy
作者:	Hsu, T.-T.;Kao, C.-T.;Chen, Y.-W.;Huang, T.-H.;Yang, J.-J.;Shie, M.-Y.
关键词:	anti-bacterial;Calcium silicate cement;cementogenesis;CO2 laser;human periodontal ligament cell
日期:	2015
上传时间:	2017-08-09T04:42:28Z (UTC)
出版者:	Institute of Physics Publishing
ISSN:	16122011
摘要:	Calcium silicate-based material (CS) has been successfully used in dental clinical applications. Some researches show that the antibacterial effects of CO<inf>2</inf> laser irradiation are highly efficient when bacteria are embedded in biofilm, due to a photo-thermal mechanism. The purpose of this study was to confirm the effects of CO<inf>2</inf> laser irradiation on CS, with regard to both material characterization and human periodontal ligament cell (hPDLs) viability. CS was irradiated with a dental CO<inf>2</inf> laser using directly mounted fiber optics in wound healing mode with a spot area of 0.25 cm2, and then stored in an incubator at 100% relative humidity and 37 °C for 1 d to set. The hPDLs cultured on CS were analyzed, along with their proliferation and odontogenic differentiation behaviors. The results indicate that the CO<inf>2</inf> laser irradiation increased the amount of Ca and Si ions released from the CS, and regulated cell behavior. CO<inf>2</inf> laser-irradiated CS promoted cementogenic differentiation of hPDLs, with the increased formation of mineralized nodules on the substrate's surface. It also up-regulated the protein expression of multiple markers of cementogenic and the expression of cementum attachment protein. The current study provides new and important data about the effects of CO<inf>2</inf> laser irradiation on CS. Taking cell functions into account, the Si concentration released from CS with laser irradiated may be lower than a critical value, and this information could lead to the development of new regenerative therapies for dentin and periodontal tissue. © 2015 Astro Ltd.
URI:	http://dx.doi.org/10.1088/1612-2011/12/5/055602 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928975081&doi=10.1088%2f1612-2011%2f12%2f5%2f055602&partnerID=40&md5=e46676e2443d8361c55a969d614f3136 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18231
關聯:	Laser Physics Letters 12(5)
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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