The synergistic effect on osteogenic differentiation of human mesenchymal stem cells by diode laser-treated stimulating human umbilical vein endothelial cells

doi:10.1088/1612-2011/13/2/025604

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题名:	The synergistic effect on osteogenic differentiation of human mesenchymal stem cells by diode laser-treated stimulating human umbilical vein endothelial cells
作者:	Kao, C.-T.;Hsu, T.-T.;Huang, T.-H.;Wu, Y.-T.;Chen, Y.-W.;Shie, M.-Y.
关键词:	co-culture;diode laser;human mesenchymal stem cell;human umbilical vein endothelial cell;osteogenesis
日期:	2016
上传时间:	2017-08-09T04:42:02Z (UTC)
出版者:	Institute of Physics Publishing
ISSN:	16122011
摘要:	Angiogenesis plays an important role in determining the biostimulation of bone regeneration, in either new bone or blood vessel formation. Human umbilical cord cells (HUVECs) are important effector cells in angiogenesis and are indispensable for osteogenesis and for their heterogeneity and plasticity. However, there are very few studies about the effects of HUVECs on diode laser-stimulated/regulated osteogenesis. In this study, we used diode laser as a model biostimulation to examine the role of HUVECs on laser-stimulated osteogenesis. Several bone formation-related proteins were also significantly up-regulated by the diode laser stimulation, indicating that HUVECs may participate in diode laser-stimulated osteogenesis. Interestingly, when human mesenchymal stem cells (hMSCs) cultured with HUVECs were diode laser-treated, the osteogenesis differentiation of the hMSCs was significantly promoted, indicating the important role of HUVECs in diode laser-enhanced osteogenesis. Adequately activated HUVECs are vital for the success of diode laser-stimulated hard-tissue regeneration. These findings provided valuable insights into the mechanism of diode laser-stimulated osteogenic differentiation, and a strategy to optimize the evaluation system for the in vitro osteogenesis capacity of laser treatment in periodontal repair. © 2016 Astro Ltd.
URI:	http://dx.doi.org/10.1088/1612-2011/13/2/025604 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957673133&doi=10.1088%2f1612-2011%2f13%2f2%2f025604&partnerID=40&md5=5fc04d5f8dd1a50f0adff0b596de6af0 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18221
關聯:	Laser Physics Letters 13(2) ,-
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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