The clinical significance of the insulin-like growth factor-1 receptor polymorphism in non-small-cell lung cancer with epidermal growth factor receptor mutation

doi:10.3390/ijms17050763

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/18199

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题名:	The clinical significance of the insulin-like growth factor-1 receptor polymorphism in non-small-cell lung cancer with epidermal growth factor receptor mutation
作者:	Liu, T.-C.;Hsieh, M.-J.;Liu, M.-C.;Chiang, W.-L.;Tsao, Tsao T.C.-Y.;Yang, S.-F.
关键词:	Epidermal growth factor receptor;Genetic variants;Insulin-like growth factor 1 receptor;Non-small-cell lung carcinoma
日期:	2016
上传时间:	2017-08-09T03:25:33Z (UTC)
出版者:	MDPI AG
ISSN:	16616596
摘要:	The insulin-like growth factor 1 (IGF1) signaling pathway mediates multiple cancer cell biological processes. IGF1 receptor (IGF1R) expression has been used as a reporter of the clinical significance of non-small-cell lung carcinoma (NSCLC). However, the association between IGF1R genetic variants and the clinical utility of NSCLC positive for epidermal growth factor receptor (EGFR) mutation is not clear. The current study investigated the association between the IGF1R genetic variants, the occurrence of EGFR mutations, and clinicopathological characteristics in NSCLC patients. A total of 452 participants, including 362 adenocarcinoma lung cancer and 90 squamous cell carcinoma lung cancer patients, were selected for analysis of IGF1R genetic variants (rs7166348, rs2229765, and rs8038415) using real-time polymerase chain reaction (PCR)genotyping. The results indicated that GA + AA genotypes of IGF1R rs2229765 were significantly associated with EGFR mutation in female lung adenocarcinoma patients (odds ratio (OR) = 0.39, 95% confidence interval (CI) = 0.17-0.87). Moreover, The GA + AA genotype IGF1R rs2229765 was significantly associated with EGFR L858R mutation (p = 0.02) but not with the exon 19 in-frame deletion. Furthermore, among patients without EGFR mutation, those who have at least one polymorphic A allele of IGF1R rs7166348 have an increased incidence of lymph node metastasis when compared with those patients homozygous for GG (OR, 2.75; 95% CI, 1.20-2.31). Our results showed that IGF1R genetic variants are related to EGFR mutation in female lung adenocarcinoma patients and may be a predictive factor for tumor lymph node metastasis in Taiwanese patients with NSCLC. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
URI:	http://dx.doi.org/10.3390/ijms17050763 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969174949&doi=10.3390%2fijms17050763&partnerID=40&md5=a5d3002defc30d3e997a881192a0f8a4 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18199
關聯:	International Journal of Molecular Sciences 17(5) ,-
显示于类别:	[醫學系] 期刊論文

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