Genetic polymorphism of manganese superoxide dismutase is associated with childhood asthma

doi:10.3109/02770901003686472

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/18113

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题名:	Genetic polymorphism of manganese superoxide dismutase is associated with childhood asthma
作者:	Kuo, Chou T.-N.;Li, Y.-S.;Lue, K.-H.;Liao, C.-F.;Lin, C.-Y.;Tzeng, P.-R.;Wong, R.-H.
关键词:	Allergen;CD14;Childhood asthma;Environmental tobacco smoke;MnSOD;MPO
日期:	2010
上传时间:	2017-08-07T09:13:04Z (UTC)
ISSN:	2770903
摘要:	Objective. Cellular defenses against allergens and reactive oxygen species (ROS) exposure are critical in the pathogenesis of asthma. CD14 is a receptor for various bacterial products, such as lipopolysaccharides (LPS), and is also a mediator of inflammatory processes. Manganese superoxide dismutase (MnSOD) is an ROS scavenger, and myeloperoxidase (MPO) can convert hydrogen peroxide into hypochlorous acid; thus, they are considered to be involved in inflammatory defense. The authors conducted a case-control study to evaluate the susceptibility to childhood asthma based on CD14, MnSOD, and MPO genes. Methods. The CD14 -260, MnSOD -9, and MPO -463 genotypes were identified by polymerase chain reactions for 116 asthmatic children and 232 healthy controls. Questionnaires were administered to obtain demographic characteristics. Allergen testing used common Taiwanese aeroallergens. Results. A higher level of parental education, family history of asthma, incense burning at home, allergen-test positive, and the MnSOD Val-Ala/Ala-Ala genotypes (matched relative risk=2.0; 95 confidence interval=1.0-4.2) were significantly associated with childhood asthma. Interactions between CD14, MnSOD, MPO genotypes and allergy status were significantly associated with asthma risk in these children (all p <.001). Furthermore, atopic cases with MnSOD Val-Ala/Ala-Ala (log eosinophil 2.66/mm3, log total serum immunoglobulin E IgE 2.48 IU/ml) or Val-Val (log eosinophil 2.61/mm3, log total serum IgE 2.63 IU/ml) genotypes had elevated eosinophil counts and total serum IgE levels as compared to nonatopic cases with MnSOD Val-Val genotype (log eosinophil 2.27/mm 3, log total serum IgE 1.83 IU/ml). Conclusions. Susceptible MnSOD genotypes might modulate the development of asthma in Taiwanese children. Copyright ? 2010 Informa Healthcare USA, Inc.
URI:	http://dx.doi.org/10.3109/02770901003686472 https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953814158&doi=10.3109%2f02770901003686472&partnerID=40&md5=b264631d7c410986e787a34ed59c9297 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18113
關聯:	Journal of Asthma 47(5),532-538
显示于类别:	[醫學系] 期刊論文

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