|
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 17918/22933 (78%)
Visitors : 7406886
Online Users : 130
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/18078
|
Title: | Risk of epilepsy in patients with systemic lupus erythematosus – A retrospective cohort study |
Authors: | Tsai, J.-D.;Lin, C.-L.;Lin, C.-C.;Sung, F.-C.;Lue, K.-H. |
Keywords: | Cohort study;Epilepsy;Health insurance data;Incidence;Lupus |
Date: | 2014 |
Issue Date: | 2017-08-07T09:11:38Z (UTC)
|
ISSN: | 11766328 |
Abstract: | Background: Systemic lupus erythematosus (SLE) affects central and peripheral nervous systems, manifesting neuropsychiatry disorders that vary from subtle signs to life-threatening complications. This study compared the risk of epilepsy between a general population and patients with SLE.Methods: From the national insurance claims data of the Taiwan National Health Research Institutes, we identified 32,301 patients with newly diagnosed SLE from 1997-2010 and, for comparison, 129,204 randomly selected people without SLE; the frequencies of both groups were matched by sex, age, and diagnosis date. The incidence of epilepsy was estimated for both cohorts by the end of 2010.Results: The incidence of epilepsy was 2.86-fold higher in the SLE cohort than in the non-SLE cohort (9.10 per 10,000 person-years versus 3.18 per 10,000 person-years), with a Cox method estimated adjusted hazard ratio (aHR) of 2.33 (95% confidence interval [CI] =1.89-2.88) for the SLE cohort. The incidence increased with age in the non-SLE cohort, while it decreased with the increase of age in the SLE cohort. Compared with the non-SLE cohort, the age-specific aHR of epilepsy for the SLE cohort decreased from 8.05 (95% CI =4.30-15.0) for those aged <20 years to 0.90 (95% CI =0.57-1.42) for those aged 60 years and above (P=0.01). Comorbidities that had a significant association with epilepsy included infarction (aHR =7.62), intracerebral hemorrhage (aHR =5.75), aseptic meningoencephalitis (aHR =5.35), and psychiatric disorder (aHR =3.31).Conclusion: Patients with SLE are at higher risk of epilepsy than the general population, especially younger SLE patients. Neurologic comorbidities and psychiatric disorders increase the epilepsy risk further. ? 2014 Tsai et al. |
URI: | http://dx.doi.org/10.2147/NDT.S64323 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84907187936&doi=10.2147%2fNDT.S64323&partnerID=40&md5=4c2310c49c0af4a8c99284d35305ee18 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18078 |
Relation: | Neuropsychiatric Disease and Treatment 10,1635-1643 |
Appears in Collections: | [醫學系] 期刊論文
|
Files in This Item:
There are no files associated with this item.
|
All items in CSMUIR are protected by copyright, with all rights reserved.
|