Alleviation of Dermatophagoides microceras-induced allergy by an immunomodulatory protein, FIP-fve, from Flammulina velutipes in mice

doi:10.1080/09168451.2014.956682

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/18070

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/18070

Title:	Alleviation of Dermatophagoides microceras-induced allergy by an immunomodulatory protein, FIP-fve, from Flammulina velutipes in mice
Authors:	Chang, Y.-C.;Hsiao, Y.-M.;Hung, S.-C.;Chen, Y.-W.;Ou, C.-C.;Chang, W.-T.;Lue, K.-H.;Ko, J.-L.
Keywords:	Asthma;Der m (dermatophagoides microceras );FIP- fve (fungal immunomodulatory protein-fve);House dust mite;Immunomodulatory protein
Date:	2015
Issue Date:	2017-08-07T09:11:15Z (UTC)
ISSN:	9168451
Abstract:	Asthma is a major public health concern. Its greatest risk factor is house dust mite (HDM). Dermatophagoides microceras (Der m) is a type of HDM, and in central Taiwan, there is approximately 80% prevalence of sensitization to Der m. FIP-fve is a fungal immunomodulatory protein (FIP) isolated from the fungus Flammulina velutipes, and exhibits anti-inflammatory properties. To investigate whether FIP-fve affects Der m-induced asthma and inflammation, we evaluated hyper-responsiveness (AHR), pathological changes, and cytokines in mice. We demonstrated that oral FIP-fve decreased Der minduced airway AHR, airway inflammation, cell infiltration, and expression of cytokines in the bronchoalveolar lavage fluid of Balb/c mice. The results of this study suggest that FIP- fve suppresses asthma, inflammation, and respiratory pathogenesis stimulated by Der m. FIP-fve is able to maintain immunomodulatory activity even in simulated gastric fluid and intestinal fluid. FIP-fve could be a safe and stable agent for suppression of allergic asthma. ? 2014 Japan Society for Bioscience Biotechnology and Agrochemistry.
URI:	http://dx.doi.org/10.1080/09168451.2014.956682 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924618483&doi=10.1080%2f09168451.2014.956682&partnerID=40&md5=11e07936219e9b5856cb8ec8d20cc1c3 https://ir.csmu.edu.tw:8080/ir/handle/310902500/18070
Relation:	Bioscience, Biotechnology and Biochemistry 79(1),88-96
Appears in Collections:	[醫學系] 期刊論文

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